A <i>cis/trans</i> Test of the Effect of the First Enzyme for Histidine Biosynthesis on Regulation of the Histidine Operon is a research paper published in Journal of Bacteriology (1973). On theSindex it has a DataRank of 1.2. It has been cited 18 times, with 12 citing works in its 1-hop citation network.
Previous studies showed that when triazolalanine was added to a derepressed culture of a histidine auxotroph, repression of the histidine operon occurred as though histidine had been added (6). However, when triazolalanine was added to a derepressed culture of a strain with a mutation in the first gene of the histidine operon which rendered the first enzyme for histidine biosynthesis resistant to inhibition by histidine, repression did not occur. The studies reported here represent a cis/trans test of this effect of mutations to feedback resistance. Using specially constructed merodiploid strains, we were able to show that the wild-type allele is dominant to the mutant (feedback resistant) allele and that the effect operates in trans . We conclude that the enzyme encoded by the first gene of the histidine operon exerts its regulatory effect on the operon not by acting locally at its site of synthesis, but by acting as a freely diffusible protein.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.442
From this paper's citation signal
Citation Network Contribution
0.782
From 12 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 36% comes from its base citations and 64% from the citation network (12 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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