Cystic Fibrosis Sputum Supports Growth and Cues Key Aspects of <i>Pseudomonas aeruginosa</i> Physiology is a research paper published in Journal of Bacteriology (2005). On theSindex it has a DataRank of 12.4. It has been cited 423 times, with 200 citing works in its 1-hop citation network.
ABSTRACT The opportunistic human pathogen Pseudomonas aeruginosa causes persistent airway infections in patients with cystic fibrosis (CF). To establish these chronic infections, P. aeruginosa must grow and proliferate within the highly viscous sputum in the lungs of CF patients. In this study, we used Affymetrix GeneChip microarrays to investigate the physiology of P. aeruginosa grown using CF sputum as the sole source of carbon and energy. Our results indicate that CF sputum readily supports high-density P. aeruginosa growth. Furthermore, multiple signals, which reduce swimming motility and prematurely activate the Pseudomonas quinolone signal cell-to-cell signaling cascade in P. aeruginosa , are present in CF sputum. P. aeruginosa factors critical for lysis of the common CF lung inhabitant Staphylococcus aureus were also induced in CF sputum and increased the competitiveness of P. aeruginosa during polymicrobial growth in CF sputum.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.907
From this paper's citation signal
Citation Network Contribution
11.5
From 200 citing papers with measurable signal
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 7% comes from its base citations and 93% from the citation network (200 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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