Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease

Journal of Virology(2021)10.1128/jvi.00975-21Source: DataRank Database

Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease is a research paper published in Journal of Virology (2021). On theSindex it has a DataRank of 0. It has been cited 48 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access48 citations

Download PDF

Cite:

Linked data & code

gen nct doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (23 grants)Impact (FWCI 2.53)OA: greenTopics (95)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (7)

Anwesha Sanyal ORCID,Ravi Ojha ORCID,Jesse D. Pyle ORCID,Olli Vapalahti ORCID,Giuseppe Balistreri ORCID

Live enrichment

PubMed:34406858 PMC:PMC8513479 OpenAlex:https://openalex.org/W3193925925

Novo Nordisk Fonden

Grant: NNF16OC0022166

HHS | National Institutes of Health

Grant: NIH Maximizing Investigators' Research Award (MIRA) GM130386

Danish Technical University

Grant: research grant

Ionis Pharmaceuticals, Inc.

Grant: unrestricted funds

Harvard Virology Program

Grant: NIH training grant T32 AI07245

Suomen Akatemia

Grant: research grant 336490

EU Horizon 2020 program

Grant: VEO 874735

Helsinki University Hospital fund

Grant: TYH2018322

Suomen Akatemia

Grant: research grant 318434

NIGMS NIH HHS

Grant: R35 GM130386

NIAID NIH HHS

Grant: T32 AI007245

HHS | National Institutes of Health

Grant: NIH Maximizing Investigators' Research Award (MIRA) GM130386

Novo Nordisk Foundation

Grant: unidentified

unidentified

European Commission

Grant: 874735

Versatile Emerging infectious disease Observatory

National Institutes of Health

Grant: 5R35GM130386-02

VISUALIZATION OF SUBCELLULAR DYNAMICS IN MULTICELLULAR ORGANISMS

Research Council of Finland

Grant: 318434

Identification and characterization of the cellular regulators of Respiratory Syncytial virus infection

National Institutes of Health

Grant: 5T32AI007245-25

Molecular Basis of Viral Infectivity

Research Council of Finland

Grant: 336490

Inhibitors of SARS-Coronavirus-2 infection

Jane ja Aatos Erkon Säätiö (Jane and Aatos Erkko Foundation)

University of Helsinki Graduate Program in Microbiology and Biotechnology

Jane ja Aatos Erkon Säätiö

Jane ja Aatos Erkon Säätiö (Jane and Aatos Erkko Foundation)

University of Helsinki Graduate Program in Microbiology and Biotechnology

FWCI

2.53

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: CC BY NC ND

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8513479

publisherhttps://journals.asm.org/doi/pdf/10.1128/JVI.00975-21

journalhttps://doi.org/10.1128/jvi.00975-21

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34406858

Fields of Study

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-190301 basic medicine03 medical and health sciencesAnimalsAntiviral AgentsBenzamidinesCell Line, TumorChlorocebus aethiopsDrug SynergismEstersGuanidinesHumansHydrazonesMorpholinesPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProtease InhibitorsPyrimidinesSARS-CoV-2Serine EndopeptidasesVero CellsVirus InternalizationCOVID-19 Drug Treatment

MeSH Terms

Phosphoinositide-3 Kinase InhibitorsSARS-CoV-2COVID-19 Drug TreatmentAnimalsAntiviral AgentsBenzamidinesChlorocebus aethiopsDrug SynergismEstersGuanidinesHumansHydrazonesMorpholinesProtease InhibitorsPyrimidinesSerine EndopeptidasesVero CellsPhosphatidylinositol 3-KinasesCell Line, TumorVirus Internalization

Keywords

BiologyVirologyCoronavirusTMPRSS2PandemicViral replicationProteaseBetacoronavirusViral entrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CoronaviridaeCoronavirus disease 2019 (COVID-19)Antiviral drugDiseaseVirusImmunologyInfectious disease (medical specialty)EnzymeMedicineSynergismvirus entryCovid-19Sars-cov-2COVID-19, SARS-CoV-2, synergism, virus entryMorpholinesACE2Antiviral AgentsGuanidinesArticlePhosphatidylinositol 3-KinasesCell Line, TumorChlorocebus aethiopsAnimalsHumansProtease InhibitorsVero CellsPhosphoinositide-3 Kinase Inhibitors11832 Microbiology and virologySerine EndopeptidasesAPILIMODHydrazonesDrug SynergismEstersVirus InternalizationVirus-Cell InteractionsBenzamidinesCOVID-19 Drug TreatmentSPIKE PROTEINPyrimidinesREPLICATION

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Safety and Efficacy of Camostat Mesylate for Covid-19: a systematic review and Meta-analysis of Randomized controlled trials

10.6084/m9.figshare.26339885.v1figshare

Additional file 1 of Safety and Efficacy of Camostat Mesylate for Covid-19: a systematic review and Meta-analysis of Randomized controlled trials

10.6084/m9.figshare.26339885figshare

Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease

FAIR Checklist

Authors (7)

Funding (23 grants)

Impact

Open Access

Topics

Linked Datasets (2)

Annotations (Europe PMC)