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With age comes resilience: how mitochondrial modulation drives age-associated fluconazole tolerance in Cryptococcus neoformans

mBio(2024)10.1128/mbio.01847-24Source: DataRank Database

With age comes resilience: how mitochondrial modulation drives age-associated fluconazole tolerance in Cryptococcus neoformans is a research paper published in mBio (2024). On theSindex it has a DataRank of 0.313. It has been cited 5 times, with 5 citing works in its 1-hop citation network.

N/A

0.313DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access5 citations · 5 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE260902

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 1.40)OA: goldTopics (44)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 86%Citation Network 14%

Base Score Contribution

0.269

From this paper's citation signal

Citation Network Contribution

0.0440

From 4 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 5 citers.

Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes
The EMBO Journal20262 citations59 referencesContributes 0.019
Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance
Journal of Fungi202512 citations180 referencesContributes 0.014
Uncovering the role of mitochondrial genome in pathogenicity and drug resistance in pathogenic fungi
Frontiers in Cellular and Infection Microbiology20253 citations136 referencesContributes 0.010
Pathogenicity and virulence of Cryptococcus neoformans from an environmental perspective
Virulence202510 citations274 referencesContributes 0.009
Mitochondrial cardiolipin sequestration of caspofungin underlies Cryptococcus neoformans inherent resistance and may contribute to cardiotoxicity
bioRxiv (Cold Spring Harbor Laboratory)20260 citations49 referencesContributes 0.000

Authors (7)

Somanon Bhattacharya ORCID,Natália Kronbauer Oliveira ORCID,Nívea Pereira de Sá ORCID,Gabriel Soares Matos ORCID,Maurizio Del Poeta ORCID

Live enrichment

PubMed:39136442 PMC:PMC11389405 OpenAlex:https://openalex.org/W4401546933

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: R56 AI127704

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: R01 AI125770

BLRD VA

Grant: I01 BX002624

BLRD VA

Grant: IK6 BX005386

FWCI

1.40

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1128/mbio.01847-24

publisherhttps://doi.org/10.1128/mbio.01847-24

publisherhttps://journals.asm.org/doi/pdf/10.1128/mbio.01847-24

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39136442

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11389405

Fields of Study

Fungal Infections and StudiesAntifungal resistance and susceptibilityCytomegalovirus and herpesvirus researchCryptococcus neoformansFluconazoleMitochondriaAntifungal AgentsDrug Resistance, FungalReactive Oxygen SpeciesATP-Binding Cassette TransportersErgosterolCryptococcosisMicrobial Sensitivity TestsHumansGene Expression Regulation, Fungal

MeSH Terms

Antifungal AgentsCryptococcosisCryptococcus neoformansErgosterolHumansMicrobial Sensitivity TestsMitochondriaFluconazoleGene Expression Regulation, FungalReactive Oxygen SpeciesATP-Binding Cassette TransportersDrug Resistance, Fungal

Keywords

Cryptococcus neoformansFluconazoleCryptococcosisBiologyCryptococcusMitochondrionMicrobiologyResilience (materials science)AntifungalGeneticsPhysicsMitochondriaReactive oxygen speciesErgosterolABC transporterreplicative agingAntifungal Tolerance

Sustainable Development Goals

SDG 0: Partnerships for the goals