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Targeted repression of topA by CRISPRi reveals a critical function for balanced DNA topoisomerase I activity in the Chlamydia trachomatis developmental cycle

mBio(2024)10.1128/mbio.02584-23Source: DataRank Database

Targeted repression of topA by CRISPRi reveals a critical function for balanced DNA topoisomerase I activity in the Chlamydia trachomatis developmental cycle is a research paper published in mBio (2024). On theSindex it has a DataRank of 0. It has been cited 9 times.

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Open Access9 citations
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›Methodology & internals
datarank_citation_only_1hop_v6· scope data_onlyMethodology
Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring
Enrichment:Funding (7 grants)Impact (FWCI 2.21)OA: goldTopics (42)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)
Findable (1/2)
  • Has DOI
Accessible (1/2)
  • Open Access
Interoperable (0/2)
    Reusable (0/3)

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      Authors (4)

      Leiqiong Gao,Abigail R. Swoboda,Scot P. OuelletteORCID,Li ShenORCID
      Live enrichment
      PubMed:38265209PMC:PMC10865786OpenAlex:https://openalex.org/W4391168967

      HHS | NIH | National Institute of Allergy and Infectious Diseases

      Grant: AI146454, AI175651

      National Science Foundation

      Grant: 1810599

      CAREER: Effects of Reductive Evolution on Amino Acid Stress Responses in Bacteria

      NIAID NIH HHS

      Grant: R21 AI146454

      NIAID NIH HHS

      Grant: R21 AI175651

      National Institutes of Health

      Grant: 5R21AI175651-02

      CRISPR interference of essential stage-specific gene function in Chlamydia trachomatis

      National Institutes of Health

      Grant: 1R21AI146454-01

      Probing mechanism and outcome of Chlamydia trachomatis response to antimicrobial insults

      REP funding from LSU School of Medicine

      FWCI

      2.21

      Citation Percentile

      0.9%

      Citation Trend

      2024
      2025
      2026

      goldLicense: cc-by
      journalhttps://doi.org/10.1128/mbio.02584-23
      publisherhttps://doi.org/10.1128/mbio.02584-23
      publisherhttps://journals.asm.org/doi/pdf/10.1128/mbio.02584-23
      repositoryhttps://pubmed.ncbi.nlm.nih.gov/38265209
      repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10865786

      Fields of Study

      Reproductive tract infections researchUrinary Tract Infections ManagementCancer therapeutics and mechanisms0301 basic medicine03 medical and health sciencesChlamydia trachomatisDNA GyraseDNA Topoisomerases, Type IBacterial Proteins

      MeSH Terms

      Bacterial ProteinsChlamydia trachomatisDNA Topoisomerases, Type IDNA Gyrase

      Keywords

      Chlamydia trachomatisTopoisomeraseBiologyGenePsychological repressionComputational biologyFunction (biology)GenomeGeneticsAdaptation (eye)DNACell biologyVirologyNeuroscienceGene expressionFluoroquinoloneDNA topoisomeraseMoxifloxacinantibacterial mechanismTopaCrispriBacterial Developmental CycleDcas12MicrobiologyQR1-502DNA Topoisomerases, Type IBacterial ProteinsDNA GyraseResearch Article

      Sustainable Development Goals

      SDG 3: 3. Good healthSDG 0: Good health and well-being