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Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS that attenuates type I interferon

mBio(2025)10.1128/mbio.03395-24Source: DataRank Database

Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS that attenuates type I interferon is a research paper published in mBio (2025). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Open Access5 citations

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Enrichment:Funding (5 grants)OA: goldTopics (33)IDs (PubMed, PMC)Annotations (1)

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Authors (9)

Yan Ya,Ye Yuan ORCID,Zhenchao Zhao ORCID,Weiyu Qu,Xiangyu Huang

Live enrichment

PubMed:39998223 PMC:PMC11980361

MOST | National Natural Science Foundation of China

Grant: 32373020

MOST | National Key Research and Development Program of China

Grant: 2022YFD1800300

HHS | National Institutes of Health

Grant: R01Al145287

Welch Foundation

Grant: A-2107

National Institutes of Health

Grant: 1R01AI145287-01

Molecular basis of viral DNA sensing through the cGAS-STING pathway

goldLicense: cc-by

publisherhttps://doi.org/10.1128/mbio.03395-24

publisherhttps://journals.asm.org/doi/pdf/10.1128/mbio.03395-24

repositoryhttps://doaj.org/article/3ea11ccdec3f45d6989d85c9c86793f6

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11980361

Europe_PMChttps://europepmc.org/articles/PMC11980361

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

Cell NucleusNucleosomesCytoplasmHumansNucleotidyltransferasesInterferon Type IHistonesDNAProtein BindingImmune Evasion3C Viral ProteasesCyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase

Keywords

3C ProteaseSeneca Valley VirusNucleosomal DnaNuclear CgasCell NucleusCytoplasm3C Viral ProteasesDNACyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMicrobiologyNucleotidyltransferasesQR1-502NucleosomesHistonesInterferon Type IHumansResearch ArticleProtein BindingImmune Evasion

Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS that attenuates type I interferon

FAIR Checklist

Authors (9)

Funding (5 grants)

Open Access

Topics

Annotations (Europe PMC)