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Diverse evolutionary trajectories of Klebsiella pneumoniae carbapenemase: unraveling the impact of amino acid substitutions on β-lactam susceptibility and the role of avibactam in driving resistance

mSystems(2025)10.1128/msystems.00184-25Source: DataRank Database

Diverse evolutionary trajectories of Klebsiella pneumoniae carbapenemase: unraveling the impact of amino acid substitutions on β-lactam susceptibility and the role of avibactam in driving resistance is a research paper published in mSystems (2025). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Enrichment:Funding (7 grants)OA: goldTopics (49)IDs (PubMed)

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Authors (10)

Jinyu Huang ORCID,Chunhong Zou,Shimei Shen,Barry N. Kreiswirth ORCID,Ailong Huang ORCID

Live enrichment

PubMed:40067047

National Natural Science Foundation of China

Grant: 82072349

Basic and Applied Basic Research Foundation of Guangdong Province

Grant: 2022A1515110558 2023A1515220197

Xiangshan Talent Project of Zhuhai People's Hospital

Grant: 2023XSYC-03

Clinical Research Promotion Project of Zhuhai Peoples's Hospital

Grant: 2023LCTS-01

Program for Youth Innovation in Future Medicine of Chongqing Medical University

Grant: W0031 W0097

National Institutes of Health

Grant: R01AI090155

National Institutes of Health

Grant: 5R01AI090155-05

The molecular basis of the epidemic blaKPC gene Klebsiella

goldLicense: cc-by

publisherhttps://doi.org/10.1128/msystems.00184-25

publisherhttps://journals.asm.org/doi/pdf/10.1128/msystems.00184-25

repositoryhttps://doaj.org/article/d84998a2bd8a4a51a05c08d9d0000019

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12013264

https://pubmed.ncbi.nlm.nih.gov/40067047

Fields of Study

0301 basic medicine03 medical and health sciencesKlebsiella pneumoniaebeta-LactamasesAzabicyclo CompoundsBacterial ProteinsAmino Acid SubstitutionAnti-Bacterial AgentsMicrobial Sensitivity TestsCeftazidimeEvolution, MolecularHumansKlebsiella Infectionsbeta-LactamsDrug Combinations

MeSH Terms

Klebsiella pneumoniaebeta-LactamasesAzabicyclo CompoundsBacterial ProteinsAmino Acid SubstitutionAnti-Bacterial AgentsMicrobial Sensitivity TestsCeftazidimeEvolution, MolecularHumansKlebsiella Infectionsbeta-LactamsDrug Combinations

Keywords

phylogenetic reconstructionceftazidime-avibactamMicrobial Sensitivity Testsbeta-LactamsMicrobiologyCeftazidimeQR1-502beta-LactamasesAnti-Bacterial AgentsKlebsiella InfectionsresistanceEvolution, MolecularKlebsiella pneumoniaeDrug CombinationsKPC (Klebsiella pneumoniae carbapenemase)Bacterial ProteinsAmino Acid SubstitutionevolutionHumansAzabicyclo CompoundsResearch Article