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Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase

Microbiology Spectrum(2023)10.1128/spectrum.01403-23Source: DataRank Database

Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase is a research paper published in Microbiology Spectrum (2023). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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Enrichment:Funding (1 grants)Impact (FWCI 1.53)OA: goldTopics (51)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Javier Melendres,Patricia Escandón ORCID,Carolina Firacative ORCID,Silvia Katherine Carvajal ORCID

Live enrichment

PubMed:37341584 PMC:PMC10434158 OpenAlex:https://openalex.org/W4381469765

Dirección de Investigación e Innovación, Universidad del Rosario

Grant: IV-FPC014

FWCI

1.53

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1128/spectrum.01403-23

publisherhttps://doi.org/10.1128/spectrum.01403-23

publisherhttps://journals.asm.org/doi/pdf/10.1128/spectrum.01403-23

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37341584

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10434158

Fields of Study

Fungal Infections and StudiesAntifungal resistance and susceptibilityPeptidase Inhibition and AnalysisHumansAntifungal AgentsCryptococcus gattiiFluconazoleAzolesVoriconazoleLanosterolSterol 14-DemethylaseCryptococcus neoformansCryptococcosisMicrobial Sensitivity TestsDrug Resistance, FungalAmino Acids

MeSH Terms

Amino AcidsAntifungal AgentsAzolesCryptococcosisCryptococcus neoformansHumansLanosterolMicrobial Sensitivity TestsFluconazoleDrug Resistance, FungalCryptococcus gattiiSterol 14-DemethylaseVoriconazole

Keywords

LanosterolDemethylaseCryptococcus gattiiStereochemistryBiologySubstrate (aquarium)Substitution (logic)ChemistryCryptococcosisPharmacologyBiochemistryMicrobiologyEcologySterolGeneCryptococcus neoformansAntimicrobial resistanceColombiaVoriconazoleAzole ResistanceFluconazole ResistanceErg11

Sustainable Development Goals

SDG 0: Good health and well-being

Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase

FAIR Checklist

Authors (4)

Funding (1 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)