Cohort profile: Biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer recurrence and survival – the FOCUS Consortium is a dataset published in BMJ Open (2022). On theSindex it has a DataRank of 0.460, placing it in the top 41.3% of the data-sharing corpus. It has been cited 13 times, with 6 citing works in its 1-hop citation network. Its calibrated FAIR score is 4/100.
Ranks in the top 41% for downstream scientific impact
Linked data & code
DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Full FAIR picture · advisory
The headline score is computed from the scored criteria — the fact-shaped checks (a repository, an accession, a licence) that two independent models agree on. The advisory criteria below are real FAIR guidance but rest on judgment calls that models read differently, so they inform without moving the number.
The paper does not provide any persistent identifier for the dataset.
RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit · RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier' · FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'
“Data are available on reasonable request.”
The data are held by the authors and not deposited in a named repository.
RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed ( · NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived · NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten
No identifier for the dataset appears in the reference list or body text.
FORCE11 Joint Declaration of Data Citation Principles (2014) — data should be cited as a first- · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes · FsF-F3-01M — F-UJI: 'Metadata includes the identifier of the data it describes'
Advisory · not in the published score
“Data are available on reasonable request.”
The data availability statement points to request from the authors.
Colavizza, Hrynaszkiewicz, Staden, Whitaker & McGillivray (2020), 'The citation advantage of li · Springer Nature research data policy — Data Availability Statements: standard statement templat · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes
“Table 3 Variables available at baseline, and at 6 and 12 months follow-up within the FOCUS Consortium”
The paper provides an itemized inventory of variables in Table 3. [majority verdict 'yes' (3/5 passes agreed)]
RDA-F2-01M — 'Rich metadata is provided to allow discovery' (priority Essential) · FsF-F2-01M — F-UJI: 'Metadata includes descriptive core elements to support data findability' · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'
“Data are available on reasonable request.”
The only access route is a discretionary request to the authors, which is not a followable process.
RDA-A1.1-01D — 'Data is accessible through a free access protocol' · FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · NSTC Desirable Characteristics of Data Repositories (2022) — 'Free and Easy Access'
Advisory · not in the published score
“Data are available on reasonable request.”
The paper describes the access action but does not label the access level.
FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · RDA-A1-01M — metadata contains information to enable the user to get access to the data · COAR Controlled Vocabularies — Access Rights v1.0 (open / embargoed / restricted / metadata-onl
“Data are available on reasonable request.”
The gatekeeper is the authors via a request, a personal gatekeeper.
NIH Genomic Data Sharing Policy (NOT-OD-14-124) — controlled-access via a Data Access Committee · RDA-A1.2-01D — 'Data is accessible through an access protocol that supports authentication and · NIH DMS Policy Element 5 (NOT-OD-21-014) — Access, Distribution, or Reuse Considerations (conse
No persistence commitment or availability timing is stated for the data.
NIH DMS Plan Element 4 (NOT-OD-21-014) — Data Preservation, Access, and Associated Timelines · NSTC Desirable Characteristics (2022), Organizational Infrastructure: 'Retention Policy' · RDA-A2-01M — 'Metadata is guaranteed to remain available after data is no longer available'
No file format is named for the released data.
FsF-R1.3-02D — F-UJI: 'Data is available in a file format recommended by the target research co · RDA-R1.3-02D — data is expressed in a machine-understandable community standard · RDA-I1-01D — data uses a knowledge representation expressed in a standardised format
Advisory · not in the published score
“All cancers and medical diagnoses are classified according to International Classification of Diseases, 10th Revision codes.”
The paper uses ICD-10 codes, a community standard for diagnoses. [majority verdict 'yes' (4/5 passes agreed)]
RDA-R1.3-01M — 'Metadata complies with a community standard' (priority Essential) · RDA-R1.3-01D — 'Data complies with a community standard' · RDA-I2-01M — '(Meta)data use vocabularies that follow FAIR principles'
“The ColoCare Study (ClinicalTrials.gov identifier: NCT02328677)”— not found in the paper; verdict downgraded
The paper provides ClinicalTrials.gov identifiers for the constituent cohorts. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (4/5 passes agreed)]
RDA-I3-01M — '(meta)data include references to other (meta)data' · RDA-I3-03M — 'metadata includes qualified references to other metadata' · FsF-I3-01M — F-UJI: 'Metadata includes links between the data and its related entities'
No reuse licence is attached to the data.
RDA-R1.1-01M — 'Metadata includes information about the licence under which the data can be reu · RDA-R1.1-02M — 'Metadata refers to a standard reuse licence' · RDA-R1.1-03M — 'Metadata refers to a machine-understandable reuse licence'
No version or date is given for the dataset.
DataCite Metadata Schema 4.6 — the 'Version' property · RDA-R1.2-01M — provenance information (which version was used is provenance) · NSTC Desirable Characteristics of Data Repositories (2022) — 'Provenance', 'Retention Policy'
“Data described in the manuscript, code book and analytical code have been generated from European-based consortia and as such are subject to regulations from multiple European countries, which limit our availability to share data.”
The paper states that code is not available due to restrictions.
NIH DMS Policy Element 2 (NOT-OD-21-014) — 'Related Tools, Software and/or Code' · FAIR4RS Principles v1.0 (Chue Hong et al., 2022; RDA/FORCE11/ReSA) — FAIR Principles for Resear · FORCE11 Software Citation Principles (Smith, Katz & Niemeyer, 2016, PeerJ CS 2:e86)
“German Ministry of Education and Research, Germany, 01KT1503”
The paper lists specific grant numbers from funders.
DataCite Metadata Schema 4.6 — 'FundingReference' property (funderName, funderIdentifier, award · Crossref Funder Registry — canonical funder identifiers for funding metadata · RDA-F2-01M — rich metadata provided to allow discovery (funding is part of the descriptive reco
Advisory · not in the published score
“All biological analyses were performed at BEVITAL AS (Bergen, Norway, http://www.bevital.no ), which carried out metabolic profiling of biomarkers allocated to seven complementary analytical platforms.”
The description names the analytical platforms but not specific instruments or version tokens. [majority verdict 'partial' (4/5 passes agreed)]
RDA-R1.2-01M — 'Metadata includes provenance information according to community- specific standa · FsF-R1.2-01M — F-UJI: 'Metadata includes provenance information about data creation or generati · W3C PROV-O (W3C Recommendation, 2013) — the entity/activity/agent model of provenance
“Table 4 Measured metabolites and biomarkers within the FOCUS Consortium”
Variable definitions are provided in tables within the article. [majority verdict 'partial' (4/5 passes agreed)]
RDA-R1-01M — '(Meta)data are richly described with a plurality of accurate and relevant attribu · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data' · NIH DMS Policy Element 3 (NOT-OD-21-014) — Standards (documentation and metadata to accompany t
Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.396
From this paper's citation signal
Citation Network Contribution
0.0638
From 5 citing papers with measurable signal
Ranked by each citer's contribution to N(p) — log1p(Cq) divided by its reference count — out of 6 citers.
Rodger C. Haggitt Endowed Chair
Grant: n.a.
World Cancer Research Fund International
Grant: 2016/1620
World Cancer Research Fund International
Grant: UM 2012-5653
World Cancer Research Fund International
Grant: UW 2013-5927
World Cancer Research Fund International
Grant: UW 2015-7946
KWF Kankerbestrijding
Grant: UM-2010-4867
KWF Kankerbestrijding
Grant: UM-2012-5653
KWF Kankerbestrijding
Grant: UW2013-6397
KWF Kankerbestrijding
Grant: UW2014-6877
FWF Austrian Science Fund
Grant: API02104FW
National Institutes of Health/National Cancer Institute
Grant: P01 CA077852
National Institutes of Health/National Cancer Institute
Grant: P30 CA042014
National Institutes of Health/National Cancer Institute
Grant: P30 CA15704
National Institutes of Health/National Cancer Institute
Grant: R01 CA194663
National Institutes of Health/National Cancer Institute
Grant: R01 CA220004
National Institutes of Health/National Cancer Institute
Grant: R01CA189184
National Institutes of Health/National Cancer Institute
Grant: T32 HG008962
National Institutes of Health/National Cancer Institute
Grant: U01 CA152756
National Institutes of Health/National Cancer Institute
Grant: U01 CA206110
Wereld Kanker Onderzoek Fonds
Grant: 2014/1179
The Netherlands Organisation for Scientific Research
Grant: 016.Veni.188.082
ERA-NET on Translational Cancer Research
Grant: FOCUS I2104-B26
ERA-NET on Translational Cancer Research
Grant: MetaboCCC I 1578 – B19
German Ministry of Education and Research
Grant: 01KD2101D
German Ministry of Education and Research
Grant: 01KT1503
German Ministry of Education and Research
Grant: 01KT1512
Health Foundation Limburg
Grant: 00005739
NCI NIH HHS
Grant: R01 CA207371
NICHD NIH HHS
Grant: K12 HD043483
NCI NIH HHS
Grant: P30 CA015704
National Institutes of Health
Grant: 3P30CA042014-30S2
Cancer Center Support Grant
National Institutes of Health
Grant: 1R01CA194663-01
(PQC1) Accelerated biological aging and colon polyp to cancer progression
National Institutes of Health
Grant: 5T32HG008962-03
Training Program in Genomic Medicine
National Institutes of Health
Grant: 5R01CA207371-03
Metabolomic Strategies for Discovery and Validation of Biomarkers of Colorectal Cancer Recurrence
National Institutes of Health
Grant: 3P30CA015704-42S2
Cancer Center Support Grant
National Institutes of Health
Grant: 5R01CA189184-04
Discovery and verification of novel biomarkers of colorectal cancer recurrence
National Institutes of Health
Grant: 5U01CA152756-10
Biomarkers for Reducing Mortality of Cancers of the Colon and Esophagus
National Institutes of Health
Grant: 5U01CA206110-07
Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare Study
National Institutes of Health
Grant: 2P01CA077852-16A1
Bioinformatics/statistical support
National Institutes of Health
Grant: 1R01CA220004-01
(PQ6) Radiogenomics of colorectal polyps to assess benign proliferative vs. premalignant states.
Fields of Study
MeSH Terms
Keywords
Sustainable Development Goals