Nature, Nurture, and Cancer Risks: Genetic and Nutritional Contributions to Cancer
Nature, Nurture, and Cancer Risks: Genetic and Nutritional Contributions to Cancer is a research paper published in Annual Review of Nutrition (2017). On theSindex it has a DataRank of 4.5. It has been cited 147 times, with 122 citing works in its 1-hop citation network.
Abstract
It is speculated that genetic variants are associated with differential responses to nutrients (known as gene-diet interactions) and that these variations may be linked to different cancer risks. In this review, we critically evaluate the evidence across 314 meta-analyses of observational studies and randomized controlled trials of dietary risk factors and the five most common cancers (breast, lung, prostate, colorectal, and stomach). We also critically evaluate the evidence across 13 meta-analyses of observational studies of gene-diet interactions for the same cancers. Convincing evidence for association was found only for the intake of alcohol and whole grains in relation to colorectal cancer risk. Three nutrient associations had highly suggestive evidence and another 15 associations had suggestive evidence. Among the examined gene-diet interactions, only one had moderately strong evidence.
›Data sources & pipeline
FAIR Checklist
Context only (not used in score)- Has DOI
- Open Access
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
DataRank Breakdown
Base Score Contribution
0.750
From this paper's citation signal
Citation Network Contribution
3.7
From 104 citing papers with measurable signal
Top 5 citers driving the network score
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
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- Uncertainty in heterogeneity estimates in meta-analysesBMJ20071,260 citationsDataRank 1.1
- An exploratory test for an excess of significant findingsClinical Trials2007783 citationsDataRank 1.00
- Assessment of cumulative evidence on genetic associations: interim guidelinesInternational Journal of Epidemiology2007546 citationsDataRank 0.946
- Implausible results in human nutrition researchBMJ2013274 citationsDataRank 0.843
Why this DataRank?
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 17% comes from its base citations and 83% from the citation network (104 citing papers contributed measurable signal).
- Base score B(p)
- log1p(citation_count) — grows sub-linearly, so a paper with 1,000 citations is not 10× a paper with 100.
- Network N(p)
- Σ over citers of log1p(Cq) ÷ max(outdegreeq, 1). Being cited by a highly-cited paper with few references counts most.
- Damping factor d = 0.85
- DataRank = (1−d)·B(p) + d·N(p) — the two cards above are each already multiplied by their share.
- Self-citations excluded
- Citers sharing any OpenAlex author ID with this paper are filtered out before the network sum.
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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