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Beyond fructolysis: ketohexokinase orchestrates ER proteostasis in nutrient-stressed hepatocytes

American Journal of Physiology-Gastrointestinal and Liver Physiology(2025)10.1152/ajpgi.00235.2025Source: DataRank Database

Beyond fructolysis: ketohexokinase orchestrates ER proteostasis in nutrient-stressed hepatocytes is a research paper published in American Journal of Physiology-Gastrointestinal and Liver Physiology (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access2 citations

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Enrichment:Funding (2 grants)Impact (FWCI 1.27)OA: hybridTopics (33)IDs (PubMed, PMC, OpenAlex)Annotations (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Xiangdong Wu ORCID,Junkai Hu ORCID,Nigus D. Ambaye ORCID,Sui Seng Tee ORCID,Salaheldeen Elsaid ORCID

Live enrichment

PubMed:41138206 PMC:PMC12765227 OpenAlex:https://openalex.org/W4415547254

HHS | National Institutes of Health

Grant: R21CA245492

HHS | National Institutes of Health

Grant: R21AG084142

FWCI

1.27

Citation Percentile

0.8%

Citation Trend

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1152/ajpgi.00235.2025

publisherhttps://doi.org/10.1152/ajpgi.00235.2025

publisherhttps://journals.physiology.org/doi/pdf/10.1152/ajpgi.00235.2025

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41138206

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12765227/

Fields of Study

Diet, Metabolism, and DiseaseLiver Disease Diagnosis and TreatmentPancreatic function and diabetes

MeSH Terms

X-Box Binding Protein 1ProteostasisAnimalsEndoplasmic ReticulumEndoribonucleasesFructokinasesFructoseHumansMaleMice, Inbred C57BLProtein Serine-Threonine KinasesHepatocytesMiceTranscription Factor CHOPUnfolded Protein ResponseEndoplasmic Reticulum StressNon-alcoholic Fatty Liver Disease

Keywords

Unfolded protein responseEndoplasmic reticulumProteostasisEndoplasmic-reticulum-associated protein degradationHepatocyteXBP1Gene knockdownFunction (biology)ApoptosisER stressUnfolded protein response (UPR)MashKetohexokinase

Beyond fructolysis: ketohexokinase orchestrates ER proteostasis in nutrient-stressed hepatocytes

FAIR Checklist

Authors (5)

Funding (2 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)