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Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin

Cancer Discovery(2020)10.1158/2159-8290.cd-20-1202Source: DataRank Database

Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin is a research paper published in Cancer Discovery (2020). On theSindex it has a DataRank of 0.735. It has been cited 133 times.

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0.735DataRank · unranked

Scored on demand from live citation data

Open Access133 citations

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Linked data & code

geo arrayexpress hpa ega

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 5.22)OA: greenTopics (73)Linked Datasets (12)DataCite Reuse (12)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.735

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (38)

Zuguang Gu ORCID,Charles D. Imbusch ORCID,Nathalia A. Giese ORCID,Magdalena Büscher,Mariam Safavi

Live enrichment

PubMed:33060108 PMC:PMC9216338 OpenAlex:https://openalex.org/W3093107703

help deriving the acinar and ductal human samples

Grant: HIPO-015A

BMBF PANC-STRAT consortium

Grant: 01ZX1305C

BMBF PANC-STRAT consortium

Grant: 01ZX1605C

DKFZ-NCT

Grant: NCT3.0_2015.17

Deutsche Forschungsgemeinschaft German Research Foundation

Grant: 329628492

German Research Foundation

Grant: 1818/2-1

EMBO

Grant: 344-2013

Intramural NIH HHS

Grant: ZIA BC011798

Canadian Institutes of Health Research

Grant: unidentified

unidentified

Deutsche Forschungsgemeinschaft

Grant: 329628492/SFB 1321

Modelling and Targeting Pancreatic Cancer

CIHR

FWCI

5.22

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

green

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9216338

publisherhttps://aacrjournals.org/cancerdiscovery/article-pdf/11/3/638/1837376/638.pdf

journalhttps://doi.org/10.1158/2159-8290.cd-20-1202

repositoryhttps://pubmed.ncbi.nlm.nih.gov/33060108

Fields of Study

Epigenetics and DNA MethylationChromatin Remodeling and CancerCancer-related gene regulation0301 basic medicine03 medical and health sciencesCarcinoma, Pancreatic DuctalCell Transformation, NeoplasticCpG IslandsDNA MethylationDisease ProgressionDisease SusceptibilityGene Expression ProfilingGene Expression Regulation, NeoplasticHumansInterferonsModels, BiologicalPancreatic NeoplasmsPrognosisRepetitive Sequences, Nucleic AcidReproducibility of ResultsSignal TransductionTranscriptomeTumor Microenvironment

MeSH Terms

Cell Transformation, NeoplasticDisease SusceptibilityHumansInterferonsModels, BiologicalPancreatic NeoplasmsPrognosisRepetitive Sequences, Nucleic AcidReproducibility of ResultsSignal TransductionGene Expression Regulation, NeoplasticDisease ProgressionCpG IslandsDNA MethylationGene Expression ProfilingCarcinoma, Pancreatic DuctalTumor MicroenvironmentTranscriptome

Keywords

BiologyCancer researchComputational biologyMedicineGeneticsextensive desmoplasiaintrinsic IFN programModels, BiologicalPancreatic ductal adenocarcinomamolecular analysesTumor MicroenvironmentHumansRepetitive Sequences, Nucleic Acidddc:610ductal cell-of-originGene Expression ProfilingPDACReproducibility of ResultsDNA MethylationPrognosisbulk tumor samplesGene Expression Regulation, NeoplasticPancreatic NeoplasmsCell Transformation, NeoplasticDisease ProgressionCpG IslandsDisease SusceptibilityInterferonsTranscriptomehypomethylationCarcinoma, Pancreatic DuctalSignal Transduction

Sustainable Development Goals

SDG 0: No poverty

Additional file 1 of Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation

10.6084/m9.figshare.24030882.v1figshare

Additional file 1 of Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation

10.6084/m9.figshare.24030882figshare

Additional file 3 of Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation

10.6084/m9.figshare.24030888.v1figshare

Additional file 3 of Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation

10.6084/m9.figshare.24030888figshare

Additional file 1 of Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma

10.6084/m9.figshare.26732836.v1figshare

Additional file 1 of Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma

10.6084/m9.figshare.26732836figshare

Additional file 2 of Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma

10.6084/m9.figshare.26732839.v1figshare

Additional file 2 of Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma

10.6084/m9.figshare.26732839figshare

Additional file 3 of Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma

10.6084/m9.figshare.26732842.v1figshare

Additional file 3 of Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma

10.6084/m9.figshare.26732842figshare

Additional file 2 of Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation

10.6084/m9.figshare.24030885figshare

Additional file 2 of Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation

10.6084/m9.figshare.24030885.v1figshare

Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin

FAIR Checklist

DataRank Breakdown

Authors (38)

Funding (12 grants)

Impact

Open Access

Topics

Linked Datasets (12)

Annotations (Europe PMC)