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Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS–MAPK Pathway Inhibition in Pancreatic Cancer

Cancer Discovery(2022)10.1158/2159-8290.cd-22-0044Source: DataRank Database

Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS–MAPK Pathway Inhibition in Pancreatic Cancer is a research paper published in Cancer Discovery (2022). On theSindex it has a DataRank of 0. It has been cited 77 times.

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Open Access77 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (9 grants)Impact (FWCI 9.83)OA: bronzeTopics (33)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (20)

Jingjie Hu ORCID,Charles Cai ORCID,Nathan P. Ward ORCID,Anthony Venida ORCID,Callum Foakes ORCID

Live enrichment

PubMed:35771494 PMC:PMC9444964 OpenAlex:https://openalex.org/W4283739590

NCI

Grant: R01CA240603

NCI

Grant: R01CA260249

NIH Director’s New Innovator Award

Grant: DP2CA216364

NCI

Grant: R37CA230042

NIH NCI

Grant: K08 CA21842002

NIH NCI

Grant: P50CA127003

NCI NIH HHS

Grant: K08 CA218420

NIGMS NIH HHS

Grant: T32 GM136547

NIDDK NIH HHS

Grant: R01 DK124384

FWCI

9.83

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

bronze

journalhttps://aacrjournals.org/cancerdiscovery/article-pdf/12/9/2198/3203734/2198.pdf

publisherhttps://aacrjournals.org/cancerdiscovery/article-pdf/12/9/2198/3203734/2198.pdf

publisherhttps://aacrjournals.org/cancerdiscovery/article-pdf/doi/10.1158/2159-8290.CD-22-0044/3174004/cd-22-0044.pdf

publisherhttps://aacrjournals.org/cancerdiscovery/article-pdf/doi/10.1158/2159-8290.CD-22-0044/3185907/cd-22-0044.pdf

journalhttps://doi.org/10.1158/2159-8290.cd-22-0044

Fields of Study

Autophagy in Disease and TherapyMitochondrial Function and PathologyCell death mechanisms and regulation

MeSH Terms

Biological AvailabilityHumansIronIron-Sulfur ProteinsPancreatic NeoplasmsSulfurTranscription FactorsProto-Oncogene Proteins p21(ras)Carcinoma, Pancreatic DuctalProtein Kinase InhibitorsNuclear Receptor Coactivators

Keywords

LysosomeAutophagyDownregulation and upregulationMAPK/ERK pathwayCell biologyKRASMitochondrial biogenesisCancer researchCancer cellBiologyChemistryMitochondrionSignal transductionCancerBiochemistryGeneApoptosisMutationGenetics

Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS–MAPK Pathway Inhibition in Pancreatic Cancer

FAIR Checklist

Authors (20)

Funding (9 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)