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CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2 - and TET2 -mutant Cells

Cancer Discovery(2024)10.1158/2159-8290.cd-23-1092Source: DataRank Database

CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2 - and TET2 -mutant Cells is a research paper published in Cancer Discovery (2024). On theSindex it has a DataRank of 0. It has been cited 11 times.

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Open Access11 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (29 grants)Impact (FWCI 3.25)OA: greenTopics (41)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (25)

Shoron Mowla ORCID,Meaghan Boileau ORCID,Anthony R. Martinez Benitez ORCID,Junya Sango ORCID,Maya Bagish

Live enrichment

PubMed:38819218 PMC:PMC11452290 OpenAlex:https://openalex.org/W4399213350

National Cancer Institute

Grant: F31 CA257367

National Cancer Institute

Grant: F99 CA274656

National Cancer Institute

Grant: K08 CA267058

National Cancer Institute

Grant: P50 CA254838

National Cancer Institute

Grant: R01 CA176745

National Cancer Institute

Grant: R01 CA259273

National Cancer Institute

Grant: P01 CA066996

National Cancer Institute

Grant: K08 CA241371

National Cancer Institute

Grant: R35 CA197594

National Cancer Institute

Grant: P30 CA008748

NCI NIH HHS

Grant: P01 CA108671

NIA NIH HHS

Grant: U01 AG077925

NCI NIH HHS

Grant: R01 CA260711

NCI NIH HHS

Grant: K99 CA248460

NCI NIH HHS

Grant: R00 CA252005

NCI NIH HHS

Grant: R00 CA248460

NCI NIH HHS

Grant: K99 CA252005

Leukemia Research Foundation

Geoffrey Beene Foundation (GBF)

'la Caixa' Foundation

Leukemia Research Foundation (LRF)

Fonds de Recherche du Québec - Santé

Geoffrey Beene Foundation

'la Caixa' Foundation ('la Caixa')

Fonds de Recherche du Québec - Santé (FRQS)

Leukemia Research Foundation (LRF)

'la Caixa' Foundation ('la Caixa')

Fonds de Recherche du Québec - Santé (FRQS)

Geoffrey Beene Foundation (GBF)

FWCI

3.25

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

green

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11452290/pdf/nihms-2000755.pdf

publisherhttps://aacrjournals.org/cancerdiscovery/article-pdf/doi/10.1158/2159-8290.CD-23-1092/3458952/cd-23-1092.pdf

publisherhttps://aacrjournals.org/cancerdiscovery/article-pdf/doi/10.1158/2159-8290.CD-23-1092/3484755/cd-23-1092.pdf

publisherhttps://aacrjournals.org/cancerdiscovery/article-pdf/14/10/1860/3500441/cd-23-1092.pdf

Fields of Study

Acute Myeloid Leukemia ResearchMyeloproliferative Neoplasms: Diagnosis and TreatmentEpigenetics and DNA MethylationJumonji Domain-Containing Histone DemethylasesHematopoietic Stem CellsHumansDioxygenasesIsocitrate DehydrogenaseMutationDNA-Binding ProteinsCRISPR-Cas SystemsProto-Oncogene ProteinsGenotypeMiceAnimals

MeSH Terms

AnimalsDNA-Binding ProteinsGenotypeHematopoietic Stem CellsHumansIsocitrate DehydrogenaseMutationProto-Oncogene ProteinsDioxygenasesMiceJumonji Domain-Containing Histone DemethylasesCRISPR-Cas Systems

Keywords

BiologyHaematopoiesisProgenitor cellCell biologyEx vivoMutantBone marrowStem cellCRISPRCancer researchGeneticsImmunologyIn vivoGene

Sustainable Development Goals

SDG 0: Good health and well-being