The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins is a research paper published in Neurodegenerative Diseases (2006). On theSindex it has a DataRank of 2.6. It has been cited 62 times, with 50 citing works in its 1-hop citation network.
It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the characterization of APP functions was markedly hampered by the high redundancy between APP and the related APP family members amyloid precursor-like proteins 1 and 2. The generation and analyses of combined gene deficiencies for APP and amyloid precursor-like proteins in mice finally marked the beginning of uncovering the in vivo roles of these proteins in mammals. In the current review, we summarize recent insights into the functions of the APP gene family from mice lacking one, two or all three family members.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.621
From this paper's citation signal
Citation Network Contribution
1.9
From 43 citing papers with measurable signal
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 24% comes from its base citations and 76% from the citation network (43 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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