Hypothalamic Thyrotropin-Releasing Hormone Regulates Pituitary Thyrotropin Beta- and Alpha-Subunit mRNA Levels in the Rat is a research paper published in Neuroendocrinology (2008). On theSindex it has a DataRank of 0.566. It has been cited 10 times, with 9 citing works in its 1-hop citation network.
It has been controversial whether thyrotropin-releasing hormone (TRH) may be involved in the regulation of biosynthesis of anterior pituitary thyroid-stimulating hormone (TSH), whereas TRH is well known to control the secretion of TSH from anterior pituitaries. We therefore studied the effect of the destruction of paraventricular nuclei (PVN), containing TRH neuronal cell bodies, on anterior pituitary TSH β- and α-subunit mRNA levels in the thyroidectomized rat. Median eminence TRH contents and serum TSH levels significantly decreased even 1 day after PVN destruction, whereas anterior pituitary TSH β- and α-subunit mRNA levels did not change. In contrast, these mRNA levels significantly descreased by 3 days after PVN destruction. Growth hormone mRNA levels were not affected during 7 days after PVN destruction. Although the involvement of other factors related to the PVN is not totally excluded, these results raise the strong possibility that hypothalamic TRH regulates anterior pituitary TSH mRNA levels.
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Base Score Contribution
0.360
From this paper's citation signal
Citation Network Contribution
0.207
From 7 citing papers with measurable signal
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 64% comes from its base citations and 36% from the citation network (7 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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