Genes for Apolipoprotein B and Microsomal Triglyceride Transfer Protein Are Expressed in the Heart is a research paper published in Circulation (1998). On theSindex it has a DataRank of 5.0. It has been cited 132 times, with 109 citing works in its 1-hop citation network.
Background —Expression of both the apolipoprotein B (apoB) gene and the microsomal triglyceride transfer protein (MTP) gene is required for the assembly and secretion of triglyceride-rich lipoproteins in the liver and intestine. Both genes have been assumed to be silent in the heart. Methods and Results —Northern blot and RNase protection analyses showed that the apoB and MTP genes were expressed in the hearts of mice and humans. In situ hybridization studies revealed that the apoB mRNA was produced in cardiac myocytes. Electron microscopy of human cardiac myocytes revealed lipid-staining particles of relatively small diameter (≈250 Å) within the Golgi apparatus. Conclusions —These studies strongly suggest that the heart synthesizes and secretes apoB-containing lipoproteins.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.734
From this paper's citation signal
Citation Network Contribution
4.2
From 98 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 15% comes from its base citations and 85% from the citation network (98 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
Click a node to highlight its connections. Use scroll to zoom. Drag to pan.