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Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

Circulation(2020)10.1161/circulationaha.119.042339Source: DataRank Database

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy is a research paper published in Circulation (2020). On theSindex it has a DataRank of 0. It has been cited 332 times.

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Open Access332 citations

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Enrichment:Funding (20 grants)Impact (FWCI 27.40)OA: hybridTopics (96)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (4)

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Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (28)

Amanda C. Garfinkel ORCID,Gabriela Venturini ORCID,Hiroko Wakimoto ORCID,Giuliana G. Repetti ORCID,Lorenzo Álamo ORCID

Live enrichment

PubMed:31983222 PMC:PMC7077965 OpenAlex:https://openalex.org/W3001201582

NCATS NIH HHS

Grant: UL1 TR001863

NHLBI NIH HHS

Grant: R01 HL080494

NHLBI NIH HHS

Grant: R01 HL084553

British Heart Foundation

Grant: RG/12/16/29939

NHLBI NIH HHS

Grant: P50 HL112349

British Heart Foundation

Grant: RG/18/9/33887

Wellcome Trust

Grant: 206466/Z/17/Z

NHLBI NIH HHS

Grant: U01 HL117006

NHLBI NIH HHS

Grant: F31 HL149334

British Heart Foundation

Grant: CH/1992001/6764

NHLBI NIH HHS

Grant: U01 HL098166

Wellcome Trust

Grant: 206466

Mechanisms by which missense variants in myosin and myosin binding protein C alter cellular contractility in genetic cardiomyopathies.

National Institutes of Health

Grant: 5R01HL080494-16

Defining Genetic Architecture and Pathways of DCM

National Institutes of Health

Grant: 5U01HL117006-03

HCMR Novel Markers of Prognosis in Hypertrophic Cardiomyopathy

National Institutes of Health

Grant: 4P50HL112349-04

Using Genetics For Early Phenotyping & Prevention of Hypertrophic Cardiomyopathy

National Institutes of Health

Grant: 5R01HL080494-03

Defining Pathways from Gene Mutation to Heart Failure

National Institutes of Health

Grant: 2R01HL084553-10A1

Genetic Signals in Ventricular Hypertrophy

National Institutes of Health

Grant: 5U01HL098166-05

Mapping Transcriptional Networks in Cardiac Development

Howard Hughes Medical Institute

FWCI

27.40

Citation Percentile

1.0%

Citation Trend

2019

2020

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.119.042339

publisherhttps://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.119.042339

publisherhttps://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.119.042339

journalhttps://doi.org/10.1161/circulationaha.119.042339

repositoryhttps://pubmed.ncbi.nlm.nih.gov/31983222

Fields of Study

Cardiomyopathy and Myosin StudiesNuclear Structure and FunctionCardiovascular Effects of Exercise0303 health sciences03 medical and health sciencesAdenosine TriphosphatasesAnimalsCardiac MyosinsCardiomyopathy, HypertrophicCells, CulturedEnergy MetabolismHumansInduced Pluripotent Stem CellsMiceMolecular Dynamics SimulationMuscle RelaxationMutation, MissenseMyocardial ContractionMyocytes, CardiacMyosin Heavy ChainsProtein ConformationSarcomeres

MeSH Terms

Adenosine TriphosphatasesAnimalsCardiomyopathy, HypertrophicCells, CulturedEnergy MetabolismHumansMuscle RelaxationMyocardial ContractionProtein ConformationSarcomeresMyosin Heavy ChainsMutation, MissenseCardiac MyosinsMyocytes, CardiacMiceMolecular Dynamics SimulationInduced Pluripotent Stem Cells

Keywords

MyosinSarcomereHypertrophic cardiomyopathyMYH7Missense mutationMedicineAllosteric regulationCardiomyopathyMyocyteCell biologyBiophysicsBiochemistryInternal medicineBiologyMutationHeart failureGeneMyosin light-chain kinaseCardiomyopathy, hypertrophicMyosinsCardiovascular Physiological PhenomenaSarcomeresProtein ConformationMuscle RelaxationMolecular Mechanisms of Muscle Regeneration and AtrophyhypertrophicMiceOriginal Research ArticlesEnzymes and CoenzymesMyocytes, CardiacAmino AcidsCells, Culturedcardiomyopathy; cardiovascular physiological phenomena; hypertrophic; myosins; sarcomeresAdenosine TriphosphatasesDiagnosis and Management of Arrhythmogenic Right Ventricular Cardiomyopathyand ProteinsDiagnosis and Management of Hypertrophic CardiomyopathyLife SciencesCardiovascular DiseasesCardiology and Cardiovascular MedicineEMC COEUR-09ReceptorInduced Pluripotent Stem CellsMutation, MissenseMolecular Dynamics SimulationBiochemistry, Genetics and Molecular BiologyHealth SciencesAnimalsHumansMolecular BiologyMyosin Heavy ChainsMyostatinMyocardial ContractionCellular and Molecular PhysiologyPeptidesEnergy MetabolismCardiac Myosins

Sustainable Development Goals

SDG 2: 2. Zero hungerSDG 3: 3. Good healthSDG 7: 7. Clean energySDG 0: Affordable and clean energy

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

FAIR Checklist

Authors (28)

Funding (20 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)