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A rational mouse model to detect on-target, off-tumor CAR T cell toxicity

JCI Insight(2020)10.1172/jci.insight.136012Source: DataRank Database

A rational mouse model to detect on-target, off-tumor CAR T cell toxicity is a research paper published in JCI Insight (2020). On theSindex it has a DataRank of 0. It has been cited 102 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access102 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 3.95)OA: goldTopics (75)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Caroline Sands ORCID,Tong Da ORCID,John Scholler ORCID,Kathleen Graham ORCID,Elizabeth L. Buza ORCID

Live enrichment

PubMed:32544101 PMC:PMC7453898 OpenAlex:https://openalex.org/W3035762342

Canadian Institutes of Health Research

Grant: 201511FIW-360137-192761

NIH

Grant: U54-CA244711

NCI NIH HHS

Grant: U54 CA244711

Canadian Institutes of Health Research

Grant: unidentified

unidentified

National Institutes of Health

Grant: 3U54CA244711-01S2

Engineering the Next Generation of T Cells

FWCI

3.95

Citation Percentile

1.0%

Influential Citations

Citation Trend

2020

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2026

goldLicense: cc-by

journalhttp://insight.jci.org/articles/view/136012/files/pdf

GOLDhttp://insight.jci.org/articles/view/136012/files/pdf

publisherhttp://insight.jci.org/articles/view/136012/files/pdf

publisherhttps://insight.jci.org/articles/view/136012/files/pdf

journalhttps://doi.org/10.1172/jci.insight.136012

Fields of Study

CAR-T cell therapy researchVirus-based gene therapy researchViral Infectious Diseases and Gene Expression in InsectsMedicineBiology0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsCell Line, TumorDisease Models, AnimalGene Expression RegulationHumansImmunotherapy, AdoptiveInterferon-gammaLiverMiceErb-b2 Receptor Tyrosine KinasesReceptors, Antigen, T-CellReceptors, Chimeric AntigenSingle-Chain AntibodiesT-LymphocytesXenograft Model Antitumor Assays

MeSH Terms

Receptors, Chimeric AntigenAnimalsDisease Models, AnimalGene Expression RegulationHumansInterferon-gammaLiverReceptors, Antigen, T-CellT-LymphocytesImmunotherapy, AdoptiveReceptor, ErbB-2Erb-b2 Receptor Tyrosine KinasesXenograft Model Antitumor AssaysCell Line, TumorMiceSingle-Chain Antibodies

Keywords

ToxicityIn vivoPotencyCancer researchAntigenDownregulation and upregulationCellChimeric antigen receptorBiologyImmunologyChemistryPharmacologyIn vitroT cellMedicineImmune systemInternal medicineBiochemistryGeneTherapeuticsCancer ImmunotherapyReceptors, Chimeric AntigenT-LymphocytesReceptors, Antigen, T-CellImmunotherapy, AdoptiveErb-b2 Receptor Tyrosine KinasesXenograft Model Antitumor AssaysDisease Models, AnimalInterferon-gammaMiceGene Expression RegulationLiverCell Line, TumorAnimalsHumansSingle-Chain Antibodies

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being