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Targeting TNF-α–producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling

JCI Insight(2022)10.1172/jci.insight.153242Source: DataRank Database

Targeting TNF-α–producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling is a research paper published in JCI Insight (2022). On theSindex it has a DataRank of 0. It has been cited 55 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access55 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (18 grants)Impact (FWCI 3.48)OA: goldTopics (58)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Aaron Sarver,Jon Zettervall,Huocong Huang ORCID,Kexin Zheng ORCID,Rolf A. Brekken ORCID

Live enrichment

PubMed:36256464 OpenAlex:https://openalex.org/W4306708247

National Institutes of Health

Grant: R01CA181385,U54CA210190

National Institutes of Health

Grant: U54CA268069

National Institutes of Health

Grant: 5R50CA211249-02

Bioinformatics approaches to solve the "Missing Driver" problem in solid tumors

National Institutes of Health

Grant: 3R01CA181385-04S1

Stellate cells and their progenitor precursors in pancreas cancer progression

National Institutes of Health

Grant: 5U54CA210181-05

Center for Immunotherapeutic Transport Oncophysics

National Institutes of Health

Grant: 5R01CA243577-04

Targeted inhibition in stromal TGFβ activity in pancreatic cancer

National Institutes of Health

Grant: 1U54CA268069-01

Center for Multiparametric Imaging of Tumor Immune Microenvironments

National Institutes of Health

Grant: 5K99CA252009-02

Function of mesothelial cells in the tumor microenvironment of pancreatic ductal adenocarcinoma

National Institutes of Health

Grant: 1R01CA245550-01A1

A platform to functionally sort and analyze tumor cells within combinatorial metastatic micorenvironments

National Institutes of Health

Grant: 3U54CA210190-03S3

Center for Modeling Tumor Cell Migration Mechanics

NCI NIH HHS

Grant: P30 CA077598

NCI NIH HHS

Grant: K99 CA252009

NCI NIH HHS

Grant: R50 CA211249

NCI NIH HHS

Grant: R01 CA245550

NCI NIH HHS

Grant: R01 CA181385

NCI NIH HHS

Grant: U54 CA210190

NCI NIH HHS

Grant: R01 CA243577

NCI NIH HHS

Grant: U54 CA210181

FWCI

3.48

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1172/jci.insight.153242

publisherhttps://doi.org/10.1172/jci.insight.153242

publisherhttps://insight.jci.org/articles/view/153242/files/pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36256464

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9746819

Fields of Study

Immune cells in cancerImmune Cell Function and InteractionIL-33, ST2, and ILC Pathways0301 basic medicine03 medical and health sciencesMiceAnimalsTumor Necrosis Factor-alphaInterleukin-33Pancreatic NeoplasmsCarcinoma, Pancreatic DuctalMacrophagesTumor Microenvironment

MeSH Terms

Interleukin-33AnimalsMacrophagesPancreatic NeoplasmsTumor Necrosis Factor-alphaCarcinoma, Pancreatic DuctalMiceTumor Microenvironment

Keywords

Pancreatic cancerCancer researchImmunityTumor necrosis factor alphaMacrophageChemistrySignal transductionCancerCell biologyMedicineImmunologyBiologyImmune systemInternal medicineBiochemistryIn vitroMiceTumor MicroenvironmentAnimalsImmunology and MicrobiologyTumor Necrosis Factor-alphaMacrophagesMacrophage Activation and PolarizationFOS: Clinical medicineRLife SciencesInnate Lymphoid Cells in ImmunityInterleukin-33Pancreatic NeoplasmsOncologyMyeloid-derived suppressor cellsResearch ArticleCarcinoma, Pancreatic DuctalNatural Killer Cells in ImmunityCancer immunotherapyCellular immune responseGastric cancer

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being