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Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1α pathway

JCI Insight(2023)10.1172/jci.insight.163820Source: DataRank Database

Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1α pathway is a research paper published in JCI Insight (2023). On theSindex it has a DataRank of 0. It has been cited 79 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access79 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)Impact (FWCI 13.57)OA: goldTopics (41)Linked Datasets (14)DataCite Reuse (14)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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Authors (9)

Adam Gilbertsen ORCID,Xia Hong ORCID,Alexey O. Benyumov,Karen Smith ORCID,Jeremy Herrera ORCID

Live enrichment

PubMed:36656644 OpenAlex:https://openalex.org/W4317481196

NIH

Grant: R01 HL125227

National Institutes of Health

Grant: 5R01HL125227-03

Integrin-Matrix Regulation of IPF Fibroblast Phenotype

NHLBI NIH HHS

Grant: R01 HL146501

FWCI

13.57

Citation Percentile

1.0%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttp://insight.jci.org/articles/view/163820/files/pdf

publisherhttp://insight.jci.org/articles/view/163820/files/pdf

publisherhttps://insight.jci.org/articles/view/163820/files/pdf

journalhttps://doi.org/10.1172/jci.insight.163820

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36656644

Fields of Study

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisMedical Imaging and Pathology StudiesPulmonary Hypertension Research and Treatments0301 basic medicine0303 health sciences03 medical and health sciencesHumansLactic AcidIdiopathic Pulmonary FibrosisSignal TransductionMesenchymal Stem CellsHypoxia

MeSH Terms

HypoxiaHumansSignal TransductionLactic AcidIdiopathic Pulmonary FibrosisMesenchymal Stem Cells

Keywords

Hypoxia (environmental)Idiopathic pulmonary fibrosisProgenitor cellCancer researchMesenchymal stem cellCell biologyLungMedicineBiologyInternal medicineChemistryStem cellOxygenPulmonologyRMesenchymal Stem CellsStem cellsHumansLactic AcidHypoxiaResearch ArticleSignal TransductionAdult stem cells

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 1 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26231286.v1figshare

Additional file 1 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26231286figshare

Additional file 1 of Lactate facilitated mitochondrial fission-derived ROS to promote pulmonary fibrosis via ERK/DRP-1 signaling

10.6084/m9.figshare.26723055.v1figshare

Additional file 1 of Lactate facilitated mitochondrial fission-derived ROS to promote pulmonary fibrosis via ERK/DRP-1 signaling

10.6084/m9.figshare.26723055figshare

Additional file 4 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26747213figshare

Additional file 4 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26747213.v1figshare

Additional file 5 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26747216.v1figshare

Additional file 5 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26747216figshare

Additional file 3 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26747210.v1figshare

Additional file 6 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26747219.v1figshare

Additional file 6 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26747219figshare

Additional file 2 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26231401.v1figshare

Additional file 3 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26747210figshare

Additional file 2 of Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

10.6084/m9.figshare.26231401figshare

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