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Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation

JCI Insight(2023)10.1172/jci.insight.168445Source: DataRank Database

Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation is a research paper published in JCI Insight (2023). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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Enrichment:Funding (11 grants)Impact (FWCI 0.54)OA: goldTopics (47)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Benjamin J. Huang ORCID,Max Harris,Christopher Boone ORCID,Weijie Wang ORCID,Heidi Carias

Live enrichment

PubMed:37681415 PMC:PMC10544224 OpenAlex:https://openalex.org/W4386494386

Leukemia and Lymphoma Society

Grant: 5476-19

National Institutes of Health

Grant: K08 CA256489

National Institutes of Health

Grant: R37 CA72614

National Institutes of Health

Grant: R01 CA180037

National Institutes of Health

Grant: U54 CA196519

NCI NIH HHS

Grant: R37 CA072614

NCI NIH HHS

Grant: R01 CA193994

National Institutes of Health

Grant: 5U54CA196519-05

Developmental and HyperActive Ras Tumor SPORE

National Institutes of Health

Grant: 5K08CA256489-02

Co-targeting BET Bromodomain Proteins and Aberrant Signaling in AML.

National Institutes of Health

Grant: 4R01CA180037-04

(PQD1) Response and Resistance to Inhibitors of Ras Effectors in Blood Cancers

National Institutes of Health

Grant: 2R37CA072614-11

Translational Investigation of KRas &NF1 in Myeloid Leukemia

FWCI

0.54

Citation Percentile

0.6%

Citation Trend

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1172/jci.insight.168445

publisherhttps://doi.org/10.1172/jci.insight.168445

publisherhttps://insight.jci.org/articles/view/168445/files/pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37681415

repositoryhttps://escholarship.org/uc/item/23p060ms

Fields of Study

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase SignalingCellular transport and secretion0303 health sciences03 medical and health sciences

MeSH Terms

AnimalsDisease Models, AnimalGerm CellsLeukemiaMutationProto-Oncogene Proteins p21(ras)Germ-Line Mutationras ProteinsMice

Keywords

KRASMAPK/ERK pathwayGTPaseCancer researchNoonan syndromeMutationPoint mutationGuanine nucleotide exchange factorMutantBiologyAnti-apoptotic Ras signalling cascadeSignal transductionLeukemiaCell biologyChemistryGeneticsGeneOncogenesOncologyLeukemiasAnimalR610Proto-Oncogene Proteins p21(ras)MiceDisease Models, AnimalGerm CellsDisease Modelsras ProteinsMedicineAnimalsGerm-Line MutationResearch Article

Sustainable Development Goals

SDG 0: Good health and well-being

Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation

FAIR Checklist

Authors (13)

Funding (11 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)