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IFN-λ uniquely promotes CD8 T cell immunity against SARS-CoV-2 relative to type I IFN

JCI Insight(2024)10.1172/jci.insight.171830Source: DataRank Database

IFN-λ uniquely promotes CD8 T cell immunity against SARS-CoV-2 relative to type I IFN is a research paper published in JCI Insight (2024). On theSindex it has a DataRank of 0.389. It has been cited 11 times, with 8 citing works in its 1-hop citation network.

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0.389DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access11 citations · 8 citing works in its network

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Linked data & code

geo doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE253635

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (28 grants)Impact (FWCI 3.22)OA: goldTopics (68)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 96%Citation Network 4%

Base Score Contribution

0.373

From this paper's citation signal

Citation Network Contribution

0.0162

From 1 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 8 citers.

A user’s guide to designing efficient and safe mucosal vaccines: Challenges & potentials
Oxford Open Immunology20256 citations102 referencesContributes 0.019
Type III interferons may suppress viral infections by triggering cell death
bioRxiv (Cold Spring Harbor Laboratory)20240 citations33 referencesContributes 0.000
Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers
Journal of Translational Medicine20250 citations64 referencesContributes 0.000
Egyptian rousette bat macrophages elicit divergent interferon responses and cytokine storm signalling against Marburg and Sudan viruses
bioRxiv (Cold Spring Harbor Laboratory)20250 citations83 referencesContributes 0.000
Marburg and Sudan viruses elicit divergent interferon responses and cytokine storm signaling in Egyptian rousette bat macrophages
Frontiers in Immunology20250 citations82 referencesContributes 0.000

Authors (11)

Parker Denz ORCID,Adam D. Kenney ORCID,Najmus Mahfooz,Samuel Speaks ORCID,Qiaoke Gong

Live enrichment

PubMed:38973611 PMC:PMC11383353 OpenAlex:https://openalex.org/W4400399461

Ohio State University

Grant: Advancing Infection

Ohio State University

Grant: Immunity Pilot Award

American Lung Association

Grant: COVID-19

American Lung Association

Grant: Emerging Respiratory Viruses Research Award

Cystic Fibrosis Foundation

Grant: LONG19F5-CI,LONG21R3

National Institutes of Health

Grant: AI146141,AI174050,GM150503,AI130110,HL154001,AI151230,T32AI165391

American Heart Association

Grant: 24PRE1200849

NHLBI NIH HHS

Grant: R01 HL154001

NIAID NIH HHS

Grant: T32 AI165391

ORFDO NIH HHS

Grant: 75N99020D00005

NIAID NIH HHS

Grant: K22 AI146141

NIAID NIH HHS

Grant: R21 AI174050

NIGMS NIH HHS

Grant: R35 GM150503

NIDA NIH HHS

Grant: 75N95020D00005

NHLBI NIH HHS

Grant: R01 HL168501

NIAID NIH HHS

Grant: R21 AI151230

NIGMS NIH HHS

Grant: R35 GM150806

NIAID NIH HHS

Grant: 75N93022D00005

NIAID NIH HHS

Grant: R01 AI130110

NHLBI NIH HHS

Grant: 75N92020D00005

NIAID NIH HHS

Grant: 75N93023D00005

National Institutes of Health

Grant: 1R35GM150503-01

RIG-I-like receptor regulation of pulmonary inflammation and homeostasis

National Institutes of Health

Grant: 1R21AI174050-01

NON-CANONICAL MECHANISMS FOR INTERFERON-LAMBDA REGULATION OF SARS-COV-2 INFECTION

National Institutes of Health

Grant: 1K22AI146141-01A1

Mechanisms of Interferon-Lambda Programming at the Innate-Adaptive Immune Interface for Protection Against Virus Infection

National Institutes of Health

Grant: 5T32AI165391-04

Interdisciplinary Program in Microbe-Host Biology

National Institutes of Health

Grant: 5R01HL146141-03

Deciphering the Mechanisms Underlying Neuroendocrine Cell Hyperplasia of Infancy

National Institutes of Health

Grant: 5R01AI130110-08

Mechanisms of innate resistance to virus infections

National Institutes of Health

Grant: 5R01HL154001-02

Mechanistic characterization of a new master regulator of cardiac virus infections

FWCI

3.22

Citation Percentile

0.9%

Influential Citations

Citation Trend

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1172/jci.insight.171830

GOLDhttps://doi.org/10.1172/jci.insight.171830

publisherhttps://doi.org/10.1172/jci.insight.171830

publisherhttps://insight.jci.org/articles/view/171830/files/pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38973611

Fields of Study

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Medicine0301 basic medicine03 medical and health sciencesAnimalsCD8-Positive T-LymphocytesSARS-CoV-2MiceCOVID-19Interferon Type ILungSignal TransductionDisease Models, AnimalInterferon LambdaInterferonsMice, Inbred C57BLMice, KnockoutDendritic CellsHumans

MeSH Terms

COVID-19SARS-CoV-2Interferon LambdaAnimalsDendritic CellsDisease Models, AnimalHumansInterferon Type IInterferonsLungMice, Inbred C57BLSignal TransductionMice, KnockoutCD8-Positive T-LymphocytesMice

Keywords

Immune systemImmunologyImmunityCD8Acquired immune systemT cellInnate immune systemCytotoxic T cellInterferonBiologyAdjuvantIn vitroT cellsInfectious diseaseinnate immunityMouse ModelsMice, KnockoutSARS-CoV-2COVID-19Dendritic CellsCD8-Positive T-LymphocytesInterferon LambdaMice, Inbred C57BLMiceDisease Models, AnimalInterferon Type IAnimalsHumansInterferonsLungResearch ArticleSignal Transduction

Sustainable Development Goals

SDG 0: Zero hunger

IFN-λ uniquely promotes CD8 T cell immunity against SARS-CoV-2 relative to type I IFN

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (11)

Funding (28 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)