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Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment

JCI Insight(2024)10.1172/jci.insight.177141Source: DataRank Database

Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment is a research paper published in JCI Insight (2024). On theSindex it has a DataRank of 0. It has been cited 47 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access47 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 8.61)OA: goldTopics (77)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Keith Kyewalabye ORCID,Akane Yamamichi ORCID,Tiffany Chen ORCID,Su Phyu ORCID,Pavlina Chuntova ORCID

Live enrichment

PubMed:38386420 OpenAlex:https://openalex.org/W4392035071

NIH

Grant: 1R35NS105068

Panattoni Family Foundation

Grant: N/A

JSPS

Grant: Overseas Research Fellowships

National Institutes of Health

Grant: 5R35NS105068-05

Preclinical development of breakthrough immunotherapy for brain tumors

NINDS NIH HHS

Grant: R35 NS105068

FWCI

8.61

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1172/jci.insight.177141

publisherhttps://doi.org/10.1172/jci.insight.177141

publisherhttps://insight.jci.org/articles/view/177141/files/pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38386420

repositoryhttps://escholarship.org/uc/item/0gf734bx

Fields of Study

CAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology03 medical and health sciences0302 clinical medicineMiceHumansAnimalsTumor MicroenvironmentAMP-Activated Protein KinasesXenograft Model Antitumor AssaysCell Line, TumorBrainGliomaT-LymphocytesTOR Serine-Threonine Kinases

MeSH Terms

AnimalsBrainGliomaHumansT-LymphocytesXenograft Model Antitumor AssaysCell Line, TumorMiceAMP-Activated Protein KinasesTOR Serine-Threonine KinasesTumor Microenvironment

Keywords

AMPKChimeric antigen receptorCancer researchGliomaCytotoxic T cellPI3K/AKT/mTOR pathwayPharmacologyMetforminChemistryMedicineIn vitroBiologyApoptosisImmunotherapyInternal medicineCell biologyCancerInsulinKinaseBiomedical and clinical sciencesT-LymphocytesOncology and CarcinogenesisImmunology610Cancer immunotherapyOtologyAMP-Activated Protein KinasesBrain cancerCell LineMiceRare DiseasesClinical ResearchCell Line, Tumor616GeneticsTumor MicroenvironmentHumansAnimalsHypoxiaTumorTOR Serine-Threonine KinasesNeurosciencesHealth sciencesBrainGene TherapyXenograft Model Antitumor AssaysBrain DisordersOrphan DrugBiotechnologyResearch Article

Sustainable Development Goals

SDG 0: Good health and well-being