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CDK2 inhibition produces a persistent population of polyploid cancer cells

JCI Insight(2025)10.1172/jci.insight.189901Source: DataRank Database

CDK2 inhibition produces a persistent population of polyploid cancer cells is a research paper published in JCI Insight (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access2 citations

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geo gen uniprot

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.91)OA: goldTopics (51)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Zibo Chen ORCID,Xiuxia Liu ORCID,Masanori Kawakami ORCID,Adam Harned ORCID,Yeap Ng ORCID

Live enrichment

PubMed:40232858 PMC:PMC12128980 OpenAlex:https://openalex.org/W4409448132

Frederick National Laboratory for Cancer Research

Grant: Laboratory Directed Exploratory Research,(LDER)

American Cancer Society

Grant: American Cancer Society Professorship

Samuel Waxman Cancer Research Foundation

Grant: SWCRF Collaborative Grant

National Cancer Institute

Grant: #75N91019D00024

NCI NIH HHS

Grant: 75N91019D00024

FWCI

0.91

Citation Percentile

0.7%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttp://insight.jci.org/articles/view/189901/files/pdf

publisherhttp://insight.jci.org/articles/view/189901/files/pdf

publisherhttps://insight.jci.org/articles/view/189901/files/pdf

journalhttps://doi.org/10.1172/jci.insight.189901

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40232858

Fields of Study

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamicsLung Cancer Treatments and MutationsHumansAnimalsPolyploidyMiceCyclin-Dependent Kinase 2Lung NeoplasmsKinesinsApoptosisCell Line, TumorCDC2 Protein KinaseProtein Kinase InhibitorsAneuploidyXenograft Model Antitumor AssaysCell ProliferationFemale

MeSH Terms

AneuploidyAnimalsFemaleHumansLung NeoplasmsPolyploidyCDC2 Protein KinaseKinesinsApoptosisXenograft Model Antitumor AssaysCell Line, TumorProtein Kinase InhibitorsCell ProliferationCyclin-Dependent Kinase 2Mice

Keywords

PolyploidCancerCancer researchPopulationCancer cellBiologyChemistryCell biologyInternal medicinePloidyMedicineGeneticsGeneEnvironmental healthPharmacologyCell cycleTherapeuticsOncology

Sustainable Development Goals

SDG 0: Good health and well-being

CDK2 inhibition produces a persistent population of polyploid cancer cells

FAIR Checklist

Authors (14)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)