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Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors

Journal of Clinical Investigation(2020)10.1172/jci130445Source: DataRank Database

Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors is a research paper published in Journal of Clinical Investigation (2020). On theSindex it has a DataRank of 2.9. It has been cited 107 times, with 107 citing works in its 1-hop citation network.

N/A

2.9DataRank · unranked

Scored on demand from live citation data

Open Access107 citations · 107 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (17 grants)Impact (FWCI 5.82)OA: bronzeTopics (63)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 25%Citation Network 75%

Base Score Contribution

0.702

From this paper's citation signal

Citation Network Contribution

2.2

From 91 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 107 citers.

The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction
American Journal of Physiology-Renal Physiology202197 citations36 referencesContributes 0.127
Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade
Journal for ImmunoTherapy of Cancer202329 citations39 referencesContributes 0.087
Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells
Journal of Experimental & Clinical Cancer Research202139 citations53 referencesContributes 0.070
Clinicopathological Significance, Related Molecular Changes and Tumor Immune Response Analysis of the Abnormal SWI/SNF Complex Subunit PBRM1 in Gastric Adenocarcinoma
Pathology & Oncology Research20225 citations27 referencesContributes 0.066
CHEK2 deficiency increase the response to PD-1 inhibitors by affecting the tumor immune microenvironment
Cancer Letters202315 citations44 referencesContributes 0.063

Authors (16)

Lin Yang ORCID,Chen Wang ORCID,Zhao Wei ORCID,Zhenlin Ju ORCID,Wei Zhang ORCID

Live enrichment

PubMed:33016929 PMC:PMC7598069 OpenAlex:https://openalex.org/W3090197188

NCI Cancer Center Support Grant

Grant: CA016672

Department of Defense grant

Grant: OC140431

NIH R01 grant

Grant: CA181663

Cancer Prevention and Research Institute of Texas grant

Grant: RP160242

Ovarian Cancer Research Foundation grant

Grant: 5P50 CA217685-02,7U01 CA217842-03,5P50 CA098258-13,545152

Adelson Medical Research Foundation

Grant: 04-7023433

NCI NIH HHS

Grant: P50 CA098258

NCI NIH HHS

Grant: P50 CA217685

NCI NIH HHS

Grant: P30 CA016672

NCI NIH HHS

Grant: R50 CA221675

NCI NIH HHS

Grant: U01 CA217842

NINDS NIH HHS

Grant: R03 NS050840

NCI NIH HHS

Grant: R01 CA181663

National Institutes of Health

Grant: 7U01CA217842-03

Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancer

National Institutes of Health

Grant: 1P50CA217685-01

U.T. M. D. Anderson Cancer Center SPORE in Ovarian Cancer

National Institutes of Health

Grant: 3P50CA098258-15S1

MD Anderson Gynecologic SPORE for Uterine Cancers

National Institutes of Health

Grant: 1R01CA181663-01A1

Mechanisms of radioresistance and strategies for radiosensitization in OCCC

FWCI

5.82

Citation Percentile

1.0%

Influential Citations

Citation Trend

2020

2021

2022

2023

2024

2025

2026

bronze

journalhttp://www.jci.org/articles/view/130445/files/pdf

BRONZEhttp://www.jci.org/articles/view/130445/files/pdf

publisherhttp://www.jci.org/articles/view/130445/files/pdf

publisherhttps://www.jci.org/articles/view/130445/files/pdf

journalhttps://doi.org/10.1172/jci130445

Fields of Study

Chromatin Remodeling and Cancerinterferon and immune responsesCancer Mechanisms and TherapyMedicineChemistryBiology0301 basic medicine03 medical and health sciences

MeSH Terms

STING ProteinCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseAnimalsDNA-Binding ProteinsHumansMembrane ProteinsNeoplasm ProteinsNeoplasmsNucleotidyltransferasesTranscription FactorsSignal TransductionHCT116 CellsMiceProteolysisAtaxia Telangiectasia Mutated ProteinsCheckpoint Kinase 2

Keywords

ARID1ACheckpoint Kinase 2Cancer researchDNA damageImmune checkpointInnate immune systemUbiquitin ligaseCell cycle checkpointBlockadeUbiquitinBiologyImmune systemCell biologyCancerCell cycleMutationImmunologyImmunotherapyDNAGeneBiochemistryReceptorGeneticsCancer ImmunotherapyMembrane ProteinsAtaxia Telangiectasia Mutated ProteinsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHCT116 CellsNucleotidyltransferasesNeoplasm ProteinsDNA-Binding ProteinsMiceSTING ProteinNeoplasmsProteolysisAnimalsHumansSignal TransductionTranscription Factors

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Related Papers (1)

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

N/A

9.1DataRank · unranked

Nature Medicine(2020)

co-cited

10.1038/s41591-019-0750-6