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RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Journal of Clinical Investigation(2021)10.1172/jci141566Source: DataRank Database

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia is a research paper published in Journal of Clinical Investigation (2021). On theSindex it has a DataRank of 1.3. It has been cited 49 times, with 44 citing works in its 1-hop citation network.

N/A

1.3DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access49 citations · 44 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

ClinicalTrials.govNCT01185886

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (11 grants)OA: bronzeTopics (67)IDs (PubMed)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 47%Citation Network 53%

Base Score Contribution

0.587

From this paper's citation signal

Citation Network Contribution

0.670

From 28 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 44 citers.

USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis
Blood Advances202319 citations43 referencesContributes 0.070
METTL14 promotes migration and invasion of choroidal melanoma by targeting RUNX2 mRNA via m6A modification
Journal of Cellular and Molecular Medicine202216 citations45 referencesContributes 0.063
MiR-652-5p elevated glycolysis level by targeting TIGAR in T-cell acute lymphoblastic leukemia
Cell Death and Disease202215 citations45 referencesContributes 0.062
Enhancer engagement sustains oncogenic transformation and progression of B-cell precursor acute lymphoblastic leukemia
Journal of Experimental & Clinical Cancer Research20246 citations41 referencesContributes 0.047
Oncogenic Runx1–Myc axis in p53-deficient thymic lymphoma
Gene202212 citations57 referencesContributes 0.045

Authors (37)

Nitesh Sharma ORCID,Monique Nysus ORCID,Christian K. Nickl,Huining Kang ORCID,Dominique Perez

Live enrichment

PubMed:19767382

NIH National Cancer Institute

Grant: R01 CA237165,P30CA118100,U24 CA114766,R35 CA197695

NIH NCATS CTSA

Grant: 8UL1TR000041

Research Foundation Flanders

Grant: FWO G065614N

National Institutes of Health

Grant: 3P20GM121176-04S1

Effect of vaping on lung immunity

National Health and Medical Research Council (NHMRC)

Grant: 1142627

Combinatorial therapeutics in high-risk infant acute lymphoblastic leukaemia

National Institutes of Health

Grant: 5R01CA237165-02

The roles of SOCS5 in T-ALL migration and tissue infiltration

National Institutes of Health

Grant: 5R35CA197695-05

Translating genomic discoveries to improved outcomes for high risk acute leukemia

National Institutes of Health

Grant: 3P30CA118100-18S1

University of New Mexico Cancer Center Support Grant

National Health and Medical Research Council (NHMRC)

Grant: 1059804

Translational research initiatives in acute leukaemia

National Institutes of Health

Grant: 5UL1TR000041-05

University of New Mexico Clinical and Translational Science Center

National Institutes of Health

Grant: 3U24CA114766-05S2

Support for Human Specimen Banking in NCI-Supported Cancer Clinical Trials

bronzeLicense: CC BY NC ND

publisherhttp://www.jci.org/articles/view/141566/files/pdf

publisherhttps://www.jci.org/articles/view/141566/files/pdf

repositoryhttps://research-repository.uwa.edu.au/en/publications/224930c0-7d71-4eda-94b5-d805a6fc26d2

repositoryhttp://hdl.handle.net/1854/LU-8698107

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7954605

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Molecular biologyMessenger32 Biomedical and Clinical SciencesCHEMOKINE RECEPTOR CXCR4Core Binding Factor Alpha 1 SubunitPrecursor T-Cell Lymphoblastic Leukemia-LymphomaBETA-CATENINMiceCell migration/adhesionReceptorsMedicine and Health SciencesDevelopmentalTRANSCRIPTIONanzsrc-for: 31 Biological SciencesChildCancerPediatricGene RearrangementTumorOrganelle BiogenesisGENE-EXPRESSION SIGNATURESanzsrc-for: 42 Health sciencesChemotaxisTARGETING SURVIVINanzsrc-for: 3101 Biochemistry and Cell BiologyGene Expression Regulation, DevelopmentalHematologyLINEAGEGene Expression Regulation, NeoplasticChemotaxis, LeukocyteOncologyDisease ProgressionSTEM-CELLSMyeloid-Lymphoid Leukemia ProteinSignal Transduction570Receptors, CXCR4Pediatric CancerChildhood Leukemia610ACUTE MYELOID-LEUKEMIAIn Vitro Techniques3101 Biochemistry and Cell BiologyCore Binding Factor beta SubunitCell LineOSTEOBLAST DIFFERENTIATIONRare Diseasesanzsrc-for: 32 Biomedical and Clinical SciencesCell Line, TumorLeukemiasGeneticsAnimalsHumansRNA, MessengerCXCR4DRUG-RESISTANCENeoplasticHistone-Lysine N-MethyltransferaseLeukocyteHematopoiesisGene Expression Regulationanzsrc-for: 11 Medical and Health SciencesRNA31 Biological Sciences

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