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Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity

Journal of Clinical Investigation(2022)10.1172/jci160852Source: DataRank Database

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity is a research paper published in Journal of Clinical Investigation (2022). On theSindex it has a DataRank of 0. It has been cited 39 times.

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Open Access39 citations

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Enrichment:Funding (14 grants)OA: goldTopics (43)IDs (PubMed, PMC)Annotations (1)SDGs (1)

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Reusable (0/3)

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Authors (25)

Khalid Rashid ORCID,Thuc Le ORCID,Suwen Li ORCID,Hailey R. Lee ORCID,Vincent Lok ORCID

Live enrichment

PubMed:35653193 PMC:PMC9374381

NIH

Grant: T32CA009120

Hirshberg Foundation for Pancreatic Cancer Research

Grant: Seed grant

W. M. Keck Foundation

Grant: COVID 19 Research Award

NIH

Grant: 1R01CA250529-01A1

Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer

NIH

Grant: 1R01CA260678-01

Targeting KRAS and adenosine mediated immunosuppression in pancreatic cancer

NIAID NIH HHS

Grant: P30 AI152501

NCI NIH HHS

Grant: R01 CA260678

NCI NIH HHS

Grant: P30 CA016042

NCI NIH HHS

Grant: R01 CA236910

NCI NIH HHS

Grant: T32 CA009056

NCI NIH HHS

Grant: R01 CA250529

NCI NIH HHS

Grant: P01 CA244118

European Commission

Grant: 260678

Molecular studies of synaptic vesicle recycling in health and disease

National Institutes of Health

Grant: 5T32CA009120-45

UCLA Tumor Immunology Institutional Traning Grant

goldLicense: cc-by

publisherhttp://www.jci.org/articles/view/160852/files/pdf

publisherhttps://www.jci.org/articles/view/160852/files/pdf

repositoryhttps://escholarship.org/uc/item/0nb7499t

repositoryhttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191851

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9374381

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

T-LymphocytesAnimalsHumansMiceImmunologic Deficiency SyndromesPurine-Nucleoside PhosphorylasePurine NucleosidesAutoimmunityToll-Like Receptor 7

Keywords

MetabolismImmunotherapyAutoimmune diseasesimmunologyT Cell DevelopmentPurine-Nucleoside Phosphorylase* / metabolismBiomedical and clinical sciences1.1 Normal biological development and functioningT-Lymphocytes610AutoimmunityMedical and Health SciencesMiceGeneticsImmunologic Deficiency Syndromes*2.1 Biological and endogenous factorsAnimalsHumansInflammatory and immune systemRImmunologic Deficiency Syndromes500Health sciencesPurine NucleosidesBiological SciencesPurine-Nucleoside PhosphorylaseToll-Like Receptor 7Purine-Nucleoside Phosphorylase* / geneticsMedicineBiochemistry and Cell BiologyResearch Article

Sustainable Development Goals

SDG 3: 3. Good health

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity

FAIR Checklist

Authors (25)

Funding (14 grants)

Open Access

Topics

Annotations (Europe PMC)