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Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity

Journal of Clinical Investigation(2023)10.1172/jci169173Source: DataRank Database

Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity is a research paper published in Journal of Clinical Investigation (2023). On theSindex it has a DataRank of 0.720. It has been cited 30 times, with 25 citing works in its 1-hop citation network.

N/A

0.720DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access30 citations · 25 citing works in its network

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Linked data & code

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Data availability

Repositories this paper deposited data in (declared in PubMed).

ClinicalTrials.govNCT00427193

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 4.23)OA: goldTopics (63)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 72%Citation Network 28%

Base Score Contribution

0.515

From this paper's citation signal

Citation Network Contribution

0.204

From 14 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 25 citers.

Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K+ Homeostasis and Mitochondrial Function
International Journal of Biological Sciences202422 citations57 referencesContributes 0.055
Long-term fasting and its influence on inflammatory biomarkers: A comprehensive scoping review
Ageing Research Reviews202511 citations64 referencesContributes 0.039
Muscle in Endocrinology: From Skeletal Muscle Hormone Regulation to Myokine Secretion and Its Implications in Endocrine–Metabolic Diseases
Journal of Clinical Medicine202550 citations172 referencesContributes 0.023
Exploring the roles of SPARC as a proinflammatory factor and its potential as a novel therapeutic target against cardiovascular disease
American Journal of Physiology-Heart and Circulatory Physiology202412 citations125 referencesContributes 0.021
Comprehensive analysis of keloid super-enhancer networks reveals FOXP1-mediated anti-senescence mechanisms in fibrosis
Cellular & Molecular Biology Letters20255 citations88 referencesContributes 0.020

Authors (12)

Olga Spadaro ORCID,Sviatoslav Sidorov ORCID,Aileen H. Lee,Sonia Caprio ORCID,Christopher D. Morrison ORCID

Live enrichment

PubMed:37781916 PMC:PMC10541189 OpenAlex:https://openalex.org/W4387231513

National Institute on Aging

Grant: AG031797,AG045712,P01AG051459

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Grant: AR070811

Glenn Foundation for Medical Research

Grant: Glenn award

Cure Alzheimer’s Fund

Grant: Cure Alzheimer’s Fund

American Federation for Aging Research

Grant: Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research

National Research Foundation of Korea

Grant: 2022R1F1A1076368

NIAMS NIH HHS

Grant: R01 AR070811

NIDDK NIH HHS

Grant: P30 DK072476

NIA NIH HHS

Grant: R01 AG045712

NCATS NIH HHS

Grant: UL1 TR001863

NIA NIH HHS

Grant: P01 AG051459

NIA NIH HHS

Grant: R01 AG031797

NIA NIH HHS

Grant: R01 AG073969

National Institutes of Health

Grant: 5P01AG051459-04

Impact of FGF21 on healthspan and lifespan

National Institutes of Health

Grant: 5R01AR070811-03

Impact of Ketone Metabolites on Inflammasome Deactivation in Gout

National Institutes of Health

Grant: 7R01AG031797-06

Impact of Calorie Restriction on Thymopoiesis in Humans

FWCI

4.23

Citation Percentile

1.0%

Influential Citations

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1172/jci169173

GOLDhttps://doi.org/10.1172/jci169173

publisherhttps://doi.org/10.1172/jci169173

publisherhttps://www.jci.org/articles/view/169173/files/pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37781916

Fields of Study

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesFatty Acid Research and HealthMedicineEnvironmental ScienceAnimalsHumansMiceAdipose TissueDiet, High-FatInflammasomesInflammationMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinObesityOsteonectin

MeSH Terms

NLR Family, Pyrin Domain-Containing 3 ProteinAdipose TissueAnimalsHumansInflammationMice, Inbred C57BLObesityOsteonectinMiceInflammasomesDiet, High-Fat

Keywords

Matricellular proteinAdipose tissueInflammationDownregulation and upregulationInflammasomeEndocrinologyAdipocyteAdipose tissue macrophagesInternal medicineChemistryBiologyMedicineCell biologyWhite adipose tissueBiochemistryExtracellular matrixMetabolismObesityinnate immunityInflammasomesICTS (Institute of Clinical and Translational Sciences)RNLR FamilyInbred C57BLDiet, High-FatPyrin Domain-Containing 3 ProteinDietMice, Inbred C57BLHigh-FatMiceNLR Family, Pyrin Domain-Containing 3 ProteinMedicine and Health SciencesAnimalsHumansOsteonectinResearch Article

Sustainable Development Goals

SDG 0: Affordable and clean energy

Related Papers (2)

Impact of intracellular innate immune receptors on immunometabolism

N/A

4.6DataRank · unranked

Cellular and Molecular Immunology(2021)

co-cited

10.1038/s41423-021-00780-y

Single-cell and spatial detection of senescent cells using DeepScence

N/A

0.479DataRank · unranked

bioRxiv (Cold Spring Harbor Laboratory)(2023)

co-cited

10.1101/2023.11.21.568150

Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (12)

Funding (16 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)

Related Papers (2)