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Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model

Journal of Clinical Investigation(2024)10.1172/jci174647Source: DataRank Database

Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model is a research paper published in Journal of Clinical Investigation (2024). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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Enrichment:Funding (21 grants)Impact (FWCI 0.94)OA: goldTopics (70)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Steven Yu ORCID,Noah Perlmutter,Yuka Nakao,Ryota Naito ORCID,Charles C. Lin ORCID

Live enrichment

PubMed:39589811 PMC:PMC11735108 OpenAlex:https://openalex.org/W4404745341

NIH/NIAMS

Grant: K08AR072144

NIH

Grant: R01AI165706

NIH

Grant: T32GM007618

NIH

Grant: F30CA257291

NIH

Grant: R01HG011239

NIH

Grant: R01AI136972

NIH

Grant: U01HG012192

NIH

Grant: R37AI114575

Howard Hughes Medical Institute

Grant: NA

Nora Eccles Treadwell Foundation

Grant: A138451

Rheumatology Research Foundation

Grant: K Supplement Award

NIAMS NIH HHS

Grant: P30 AR075055

NIAMS NIH HHS

Grant: P30 AR070155

National Institutes of Health

Grant: 5R01HG011239-03

Mapping gene-by-environment interactions using multiplexed single cell RNA-sequencing

National Institutes of Health

Grant: 5T32GM007618-27

MEDICAL SCIENTIIST TRAINING PROGRAM

National Institutes of Health

Grant: 5F30CA257291-03

Discovery of myeloid immune features predictive of response to cancer immunotherapy in prostate cancer

National Institutes of Health

Grant: 5R01AI165706-02

Regulation of CD4 T cell tolerance by the NR4A family of nuclear receptors

National Institutes of Health

Grant: 1R37AI114575-01A1

The cell and molecular mechanisms underlying CD28 costimulation

National Institutes of Health

Grant: 5K08AR072144-03

Signaling and repertoire differences in arthritogenic T cells

National Institutes of Health

Grant: 5R01AI136972-03

Genetic regulation and immunological function of ERAP2 haplotypes

National Institutes of Health

Grant: 8U01HG012192-05

Fine mapping rheumatic disease variants using functional genomic sequencing

FWCI

0.94

Citation Percentile

0.7%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttp://www.jci.org/articles/view/174647/files/pdf

publisherhttp://www.jci.org/articles/view/174647/files/pdf

publisherhttps://www.jci.org/articles/view/174647/files/pdf

journalhttps://doi.org/10.1172/jci174647

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39589811

Fields of Study

T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and Interaction03 medical and health sciences0302 clinical medicine

MeSH Terms

AnimalsArthritis, ExperimentalArthritis, RheumatoidAutoimmune DiseasesDisease Models, AnimalFemaleMice, Inbred BALB CReceptors, Antigen, T-CellSignal TransductionCD4-Positive T-LymphocytesReceptors, Antigen, T-Cell, alpha-betaMutation, MissenseMiceZAP-70 Protein-Tyrosine KinaseTranscriptome

Keywords

SuperantigenT-cell receptorBiologyImmunologyT cellAntigenCell biologyImmune systemToleranceT cell receptorAutoimmune diseasesAutoimmunityCD4-Positive T-Lymphocytes570Biomedical and clinical sciencesReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell610Autoimmune DiseaseMedical and Health SciencesExperimentalMiceRheumatoidReceptorsGenetics2.1 Biological and endogenous factorsAnimalsInbred BALB Calpha-betaMice, Inbred BALB CZAP-70 Protein-Tyrosine KinaseAnimalArthritisInflammatory and immune systemHuman GenomeHealth sciencesBiological SciencesT-CellArthritis, ExperimentalDisease Models, AnimalMutationDisease ModelsWomen's HealthFemaleBiochemistry and Cell BiologyImmunotherapyMissenseTranscriptomeResearch ArticleSignal Transduction

Sustainable Development Goals

SDG 0: Zero hungerSDG 0: Good health and well-being

Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model

FAIR Checklist

Authors (11)

Funding (21 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)