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Mediator kinase inhibition reverses castration resistance of advanced prostate cancer

Journal of Clinical Investigation(2024)10.1172/jci176709Source: DataRank Database

Mediator kinase inhibition reverses castration resistance of advanced prostate cancer is a research paper published in Journal of Clinical Investigation (2024). On theSindex it has a DataRank of 0. It has been cited 22 times.

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Open Access22 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)Impact (FWCI 5.66)OA: goldTopics (65)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (26)

Thomas A. Hilimire ORCID,Yueying Liu ORCID,Lili Wang ORCID,Jiaxin Liang ORCID,Balázs Győrffy ORCID

Live enrichment

PubMed:38546787 PMC:PMC11093614 OpenAlex:https://openalex.org/W4393278360

National Cancer Institute

Grant: R44CA203184,R43CA203184,R43CA271996,R01CA266027,R01CA260351,P30 CA138313,P30CA062203

National Institute of General Medical Sciences

Grant: P20GM109091

U.S. Department of Defense

Grant: W81XWH-22-1-0205,W81XWH-19-1-0726

BLRD VA

Grant: I01 BX005105

NCI NIH HHS

Grant: P30 CA062203

NCI NIH HHS

Grant: R43 CA203184

NCI NIH HHS

Grant: R01 CA266027

NCI NIH HHS

Grant: R01 CA260351

NCI NIH HHS

Grant: R44 CA203184

NCI NIH HHS

Grant: P30 CA138313

NCI NIH HHS

Grant: R43 CA271996

National Institutes of Health

Grant: 3P20GM109091-08S2

METABOLIC ANALYSIS INSTRUMENTATION TO ENHANCE TARGETED THERAPEUTICS STUDIES

National Institutes of Health

Grant: 5P30CA138313-09

Medical University of South Carolina - Cancer Center Support Grant

National Institutes of Health

Grant: 1R01CA260351-01A1

Ethnicity-determined T cell responses and GARP/TGFbeta1 signaling in prostate cancer

National Institutes of Health

Grant: 5R44CA203184-03

CDK8/19 inhibitors for therapy of advanced prostate cancer

National Institutes of Health

Grant: 1R43CA271996-01A1

Preventing in vivo resistance to PI3K/AKT/mTOR inhibitors through Mediator kinase inhibition

National Institutes of Health

Grant: 5R01CA266027-04

Preventing adaptive drug resistance through Mediator kinase inhibition

National Institutes of Health

Grant: 1R43CA203184-01

CDK8/19 inhibitors for therapy of advanced prostate cancer

National Institutes of Health

Grant: 3P30CA062203-27S1

Clinical Trial Advancement and Development for Sarcomas

FWCI

5.66

Citation Percentile

1.0%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttp://www.jci.org/articles/view/176709/files/pdf

publisherhttp://www.jci.org/articles/view/176709/files/pdf

publisherhttps://www.jci.org/articles/view/176709/files/pdf

journalhttps://doi.org/10.1172/jci176709

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38546787

Fields of Study

Prostate Cancer Treatment and ResearchUbiquitin and proteasome pathwaysAdvanced Breast Cancer Therapies0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

AnimalsHumansMaleGene Expression Regulation, NeoplasticCyclin-Dependent KinasesXenograft Model Antitumor AssaysCell Line, TumorProtein Kinase InhibitorsMiceCyclin-Dependent Kinase 8Tumor MicroenvironmentProstatic Neoplasms, Castration-Resistant

Keywords

MediatorKinaseCancer researchProstate cancerCyclin-dependent kinase 8BiologyAndrogenSignal transductionCell biologyMedicineEndocrinologyInternal medicineCancerHormoneTranscriptionTherapeuticsOncologyUrologic DiseasesMale570Biomedical and clinical sciencesClinical SciencesOncology and CarcinogenesisImmunology610Castration-ResistantMedical and Health SciencesCell LineMiceCell Line, TumorGeneticsTumor MicroenvironmentHumansAnimalsProtein Kinase InhibitorsNeoplasticTumorProstatic NeoplasmsHealth sciencesXenograft Model Antitumor AssaysCyclin-Dependent KinasesGene Expression Regulation, NeoplasticBiological sciencesProstatic Neoplasms, Castration-ResistantGene Expression Regulation5.1 PharmaceuticalsResearch Article

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Mediator kinase inhibition reverses castration resistance of advanced prostate cancer

FAIR Checklist

Authors (26)

Funding (19 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)