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Tumor cell–derived spermidine promotes a protumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

Journal of Clinical Investigation(2024)10.1172/jci177824Source: DataRank Database

Tumor cell–derived spermidine promotes a protumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition is a research paper published in Journal of Clinical Investigation (2024). On theSindex it has a DataRank of 0.571. It has been cited 19 times, with 16 citing works in its 1-hop citation network.

N/A

0.571DataRank · unranked

Scored on demand from live citation data

Open Access19 citations · 16 citing works in its network

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Linked data & code

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (20 grants)Impact (FWCI 3.00)OA: goldTopics (56)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 79%Citation Network 21%

Base Score Contribution

0.449

From this paper's citation signal

Citation Network Contribution

0.122

From 9 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 16 citers.

Multi-omics analysis of polyamine metabolism implicates NT5E/CD73 in the progression of pancreatic cancer
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Frontiers in Immunology20252 citations53 referencesContributes 0.021
Quantitative Mass Spectrometry Imaging of Amino Acids Enabled by Pyridinium Salt MALDI Probe
Analytical Chemistry20251 citations42 referencesContributes 0.017
Gut microbial metabolites in cancer immunomodulation
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bioRxiv (Cold Spring Harbor Laboratory)20251 citations58 referencesContributes 0.012

Authors (26)

Juyeun Lee ORCID,Ellen S. Hong ORCID,Julia L Beilis,Sahil Dayal ORCID,Emily Wesley

Live enrichment

PubMed:39561012 PMC:PMC11735101 OpenAlex:https://openalex.org/W4404523556

Cancer Council Victoria

Grant: VG2022

Perpetual

Grant: IPAP20221259

Victorian Cancer Agency

Grant: MCRF22003

National Health and Medical Research Council

Grant: GNT1184421

National Institutes of Health

Grant: F31 CA264849,T32 GM088088,R35 NS127083,P01 CA245705,K99 CA248611,R01HL103866,P01HL147823

NCI NIH HHS

Grant: P01 CA245705

NIGMS NIH HHS

Grant: T32 GM007250

NIGMS NIH HHS

Grant: T32 GM088088

NCI NIH HHS

Grant: F31 CA264849

NCI NIH HHS

Grant: K99 CA248611

NHLBI NIH HHS

Grant: P01 HL147823

NHLBI NIH HHS

Grant: R01 HL103866

NINDS NIH HHS

Grant: R35 NS127083

National Institutes of Health

Grant: 5P01HL147823-03

Gut Microbiota and Cardiometabolic Diseases

National Institutes of Health

Grant: 1T32GM088088-01A1

Molecular Medicine Training Program

National Institutes of Health

Grant: 5F31CA264849-03

Polyamines drive glioblastoma progression

National Institutes of Health

Grant: 5R01HL103866-03

Gut flora metabolism of dietary phosphatidylcholine and cardiovascular disease

National Institutes of Health

Grant: 1K99CA248611-01A1

Role of myeloid-derived suppressor cells in local and systemic immunosuppression in glioblastoma

National Institutes of Health

Grant: 1R35NS127083-01

Contribution of Myeloid-Derived Suppressor Cells to Neuro-Inflammatory Alterations and Disease Progression in Glioblastoma

National Institutes of Health

Grant: 5P01CA245705-02

Sex-based Differences in Glioma

FWCI

3.00

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttp://www.jci.org/articles/view/177824/files/pdf

publisherhttp://www.jci.org/articles/view/177824/files/pdf

publisherhttps://www.jci.org/articles/view/177824/files/pdf

journalhttps://doi.org/10.1172/jci177824

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39561012

Fields of Study

Polyamine Metabolism and ApplicationsEpigenetics and DNA MethylationImmune Cell Function and Interaction03 medical and health sciences0302 clinical medicineGlioblastomaSpermidineAnimalsTumor MicroenvironmentHumansMiceCD8-Positive T-LymphocytesCell Line, TumorBrain NeoplasmsFemaleMaleOrnithine Decarboxylase

MeSH Terms

AnimalsBrain NeoplasmsFemaleGlioblastomaHumansMaleOrnithine DecarboxylaseSpermidineCD8-Positive T-LymphocytesCell Line, TumorMiceTumor Microenvironment

Keywords

SpermidineTumor microenvironmentCytotoxic T cellCD8Immune systemCancer researchT cellBiologyImmunologyIn vitroBiochemistryEnzymePolyaminesBrain cancerOncologyadaptive immunityMaleBrain NeoplasmsCD8-Positive T-LymphocytesOrnithine DecarboxylaseMiceCell Line, TumorAnimalsHumansFemaleGlioblastomaResearch Article

Sustainable Development Goals

SDG 0: Zero hunger