Functional consequence of pathogenic GABRA3 variants determines whether X-linked inheritance is dominant or recessive is a dataset published in Journal of Clinical Investigation (2025). On theSindex it has a DataRank of 0.165, placing it in the top 70.4% of the data-sharing corpus. It has been cited 2 times. Its calibrated FAIR score is 38/100.
Ranks in the top 70% for downstream scientific impact
Linked data & code
DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Full FAIR picture · advisory
The headline score is computed from the scored criteria — the fact-shaped checks (a repository, an accession, a licence) that two independent models agree on. The advisory criteria below are real FAIR guidance but rest on judgment calls that models read differently, so they inform without moving the number.
No persistent identifier in a PID scheme (DOI, Handle, ARK, repository accession) is given for the dataset; the article DOI and supplemental DOI are not dataset identifiers.
RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit · RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier' · FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'
No repository name is given; data are stated to be in the manuscript and supplements.
RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed ( · NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived · NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten
No identifier for the dataset appears in the reference list or body text; the only identifiers are the article DOI and supplemental DOI, which are not dataset identifiers.
FORCE11 Joint Declaration of Data Citation Principles (2014) — data should be cited as a first- · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes · FsF-F3-01M — F-UJI: 'Metadata includes the identifier of the data it describes'
Advisory · not in the published score
“All available data are presented in the main manuscript, the supplemental files, or the Supporting Data Values file.”
The statement points to the article and its supplements, not to a repository record (Colavizza category 2).
Colavizza, Hrynaszkiewicz, Staden, Whitaker & McGillivray (2020), 'The citation advantage of li · Springer Nature research data policy — Data Availability Statements: standard statement templat · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes
“The cohort consisted of 43 individuals, 18 males and 25 females, carrying missense or protein-truncating GABRA3 variants ( Supplemental Table 1 ; supplemental material available online with this article; https://doi.org/10.1172/JCI189830DS1 ).”
Dataset content is described in running prose, not as an itemised inventory [majority verdict 'partial' (3/5 passes agreed)]
RDA-F2-01M — 'Rich metadata is provided to allow discovery' (priority Essential) · FsF-F2-01M — F-UJI: 'Metadata includes descriptive core elements to support data findability' · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'
“All available data are presented in the main manuscript, the supplemental files, or the Supporting Data Values file.”
The statement gives a route to the data with no stated precondition; the data are available immediately.
RDA-A1.1-01D — 'Data is accessible through a free access protocol' · FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · NSTC Desirable Characteristics of Data Repositories (2022) — 'Free and Easy Access'
Advisory · not in the published score
“All available data are presented in the main manuscript, the supplemental files, or the Supporting Data Values file.”
No access-level label is applied; the data availability statement describes where the data reside (action), requiring inference of the level.
FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · RDA-A1-01M — metadata contains information to enable the user to get access to the data · COAR Controlled Vocabularies — Access Rights v1.0 (open / embargoed / restricted / metadata-onl
Data are openly shared in the manuscript and supplements; no gatekeeper is named for access to the human-subject data.
NIH Genomic Data Sharing Policy (NOT-OD-14-124) — controlled-access via a Data Access Committee · RDA-A1.2-01D — 'Data is accessible through an access protocol that supports authentication and · NIH DMS Policy Element 5 (NOT-OD-21-014) — Access, Distribution, or Reuse Considerations (conse
No sentence addresses when the data become available or how long they persist. [majority verdict 'no' (4/5 passes agreed)]
NIH DMS Plan Element 4 (NOT-OD-21-014) — Data Preservation, Access, and Associated Timelines · NSTC Desirable Characteristics (2022), Organizational Infrastructure: 'Retention Policy' · RDA-A2-01M — 'Metadata is guaranteed to remain available after data is no longer available'
No file format token is named for the released data.
FsF-R1.3-02D — F-UJI: 'Data is available in a file format recommended by the target research co · RDA-R1.3-02D — data is expressed in a machine-understandable community standard · RDA-I1-01D — data uses a knowledge representation expressed in a standardised format
Advisory · not in the published score
“For all clinical characteristics, human phenotype ontology terms were used whenever possible to make data comparable across individuals.”
Human Phenotype Ontology is a community standard vocabulary [majority verdict 'yes' (4/5 passes agreed)]
RDA-R1.3-01M — 'Metadata complies with a community standard' (priority Essential) · RDA-R1.3-01D — 'Data complies with a community standard' · RDA-I2-01M — '(Meta)data use vocabularies that follow FAIR principles'
“Structural mapping of the 15 missense variants reported in this study on the native mouse GABA A receptor α3 structure (PDB 8G4X).”
The paper cites the external resource PDB 8G4X (a PDB identifier) for the structure used in mapping.
RDA-I3-01M — '(meta)data include references to other (meta)data' · RDA-I3-03M — 'metadata includes qualified references to other metadata' · FsF-I3-01M — F-UJI: 'Metadata includes links between the data and its related entities'
“This work is licensed under the Creative Commons Attribution 4.0 International License.”
The data, as part of the work, are under an open standard license (CC BY 4.0). [majority verdict 'yes' (3/5 passes agreed)]
RDA-R1.1-01M — 'Metadata includes information about the licence under which the data can be reu · RDA-R1.1-02M — 'Metadata refers to a standard reuse licence' · RDA-R1.1-03M — 'Metadata refers to a machine-understandable reuse licence'
No version token or date is stated for the data snapshot.
DataCite Metadata Schema 4.6 — the 'Version' property · RDA-R1.2-01M — provenance information (which version was used is provenance) · NSTC Desirable Characteristics of Data Repositories (2022) — 'Provenance', 'Retention Policy'
No code location is provided; only third-party tools are named.
NIH DMS Policy Element 2 (NOT-OD-21-014) — 'Related Tools, Software and/or Code' · FAIR4RS Principles v1.0 (Chue Hong et al., 2022; RDA/FORCE11/ReSA) — FAIR Principles for Resear · FORCE11 Software Citation Principles (Smith, Katz & Niemeyer, 2016, PeerJ CS 2:e86)
“The Australian National Health and Medical Research Council (grant APP2019780 to PKA, MC, CAR, VWYL, and RSM). The Lundbeck Foundation (grant R383-2022-276 to RSM and PKA). The National Institute of Neurological Disorders and Stroke of the NIH (award U01HG007672 to RCS).”
Specific grant numbers are provided [majority verdict 'yes' (4/5 passes agreed)]
DataCite Metadata Schema 4.6 — 'FundingReference' property (funderName, funderIdentifier, award · Crossref Funder Registry — canonical funder identifiers for funding metadata · RDA-F2-01M — rich metadata provided to allow discovery (funding is part of the descriptive reco
Advisory · not in the published score
“The recordings were made using an Axon Multiclamp 700B amplifier, Digidata 1440A digitizer (Molecular Devices), and pCLAMP version 10 software (Molecular Devices).”
Specific hardware and software (with version tokens) are named for data production. [majority verdict 'yes' (4/5 passes agreed)]
RDA-R1.2-01M — 'Metadata includes provenance information according to community- specific standa · FsF-R1.2-01M — F-UJI: 'Metadata includes provenance information about data creation or generati · W3C PROV-O (W3C Recommendation, 2013) — the entity/activity/agent model of provenance
“Supplemental Table 1”
Variable definitions are provided in the supplementary table (inside the article), with no documentation object named as travelling with the data. [majority verdict 'partial' (3/5 passes agreed)]
RDA-R1-01M — '(Meta)data are richly described with a plurality of accurate and relevant attribu · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data' · NIH DMS Policy Element 3 (NOT-OD-21-014) — Standards (documentation and metadata to accompany t
Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.165
From this paper's citation signal
Citation Network Contribution
0
Citation network not refreshed for this result
This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.
Learn more about DataRank methodology →Australian National Health & Medical Research Council
Grant: APP1185122,APP2019780
National Institute of Neurological Disorders and Stroke of the National Institutes of Health
Grant: U01HG007672
Stiftung Michael
Grant: Canger-Janz-Fellowship
DFG
Grant: 499552394 – SFB 1597,503306912 – FOR 5547,431984000 – SFB 1453
Excellence Initiative Centre for Integrative Biological Signalling Studies
Grant: (EXC-2189)(project ID 390939984)
NINDS NIH HHS
Grant: U01 NS134350
NINDS NIH HHS
Grant: R01 NS127108
MeSH Terms
Keywords