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GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1

Journal of Clinical Investigation(2025)10.1172/jci189956Source: DataRank Database

GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1 is a research paper published in Journal of Clinical Investigation (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (4 grants)Impact (FWCI 0.41)OA: goldTopics (34)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Scarlett Acklin-Wehnert,Ratan Sadhukhan ORCID,Mousumi Patra ORCID,Fen Xia,Heba Allam ORCID

Live enrichment

PubMed:41243969 PMC:PMC12618078 OpenAlex:https://openalex.org/W4416572688

National Institutes of Health

Grant: CA188500,CA163838,CA247947

NCI NIH HHS

Grant: R01 CA188500

NCI NIH HHS

Grant: R01 CA247947

NCI NIH HHS

Grant: R01 CA163838

FWCI

0.41

Citation Percentile

0.6%

Citation Trend

2026

goldLicense: cc-by

journalhttps://doi.org/10.1172/jci189956

publisherhttps://doi.org/10.1172/jci189956

publisherhttps://www.jci.org/articles/view/189956/files/pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41243969

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12618078

Fields of Study

DNA Repair MechanismsPARP inhibition in cancer therapyBRCA gene mutations in cancer

MeSH Terms

Poly(ADP-ribose) Polymerase InhibitorsPoly (ADP-Ribose) Polymerase-1Glycogen Synthase Kinase 3 betaTumor Suppressor p53-Binding Protein 1AnimalsCarrier ProteinsDNA RepairEndodeoxyribonucleasesFemaleHumansNuclear ProteinsPhosphorylationBRCA1 ProteinTelomere-Binding ProteinsCell Line, TumorRad51 RecombinaseMiceDNA Breaks, Double-StrandedDNA End-Joining Repair

Keywords

RAD51PARP1DNA repairHomologous recombinationDNA damagePhosphorylationSynthetic lethalityPoly ADP ribose polymeraseNon-homologous end joiningGenome instabilityCell biologyOncology

GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1

FAIR Checklist

Authors (5)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)