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Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma

Molecular Cancer(2025)10.1186/s12943-025-02408-5Source: DataRank Database

Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma is a research paper published in Molecular Cancer (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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geo cellosaurus ega doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (13 grants)Impact (FWCI 1.37)OA: goldTopics (63)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)Annotations (4)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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Authors (12)

Kennedy S. Humphrey,Eduardo Cortes Gomez ORCID,Jianxin Wang ORCID,Vishnu Kumarasamy ORCID,Yin Wan ORCID

Live enrichment

PubMed:40731412 PMC:PMC12306140 OpenAlex:https://openalex.org/W4412733274

National Cancer Institute

Grant: CA267467

National Cancer Institute

Grant: R01CA279713

National Cancer Institute

Grant: R37CA275691

Pancreatic Cancer Action Network

Grant: 167025ABEL

NCI NIH HHS

Grant: L70 CA275691

NCI NIH HHS

Grant: R37 CA275961

National Institutes of Health

Grant: 5R37CA275961-03

Targeting HNF1A-mediated therapeutic resistance in pancreatic ductal adenocarcinoma

National Institutes of Health

Grant: 5P30CA016056-40

Roswell Park Cancer Institute Cancer Center Support Grant

National Institutes of Health

Grant: 1R01CA279713-01

RBFOX2 deregulation promotes pancreatic cancer progression through alternative splicing

National Institutes of Health

Grant: 5R01CA211878-03

Common Genetically Altered Pathways as Targets for Therapy in Pancreatic Cancer

Roswell Park Alliance Foundation

Hirshberg Foundation for Pancreatic Cancer Research

SAS Foundation for Cancer Research

FWCI

1.37

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://link.springer.com/content/pdf/10.1186/s12943-025-02408-5.pdf

publisherhttps://link.springer.com/content/pdf/10.1186/s12943-025-02408-5.pdf

publisherhttps://link.springer.com/article/10.1186/s12943-025-02408-5/fulltext.html

journalhttps://doi.org/10.1186/s12943-025-02408-5

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40731412

Fields of Study

Pancreatic and Hepatic Oncology ResearchFibroblast Growth Factor ResearchCancer Cells and Metastasis03 medical and health sciences0302 clinical medicineHumansCarcinoma, Pancreatic DuctalAnimalsReceptor, Fibroblast Growth Factor, Type 4MiceCell Line, TumorHepatocyte Nuclear Factor 1-alphaPancreatic NeoplasmsCell MovementGene Expression Regulation, NeoplasticNeoplasm MetastasisXenograft Model Antitumor AssaysDisease Models, Animal

MeSH Terms

AnimalsCell MovementDisease Models, AnimalHumansNeoplasm MetastasisPancreatic NeoplasmsGene Expression Regulation, NeoplasticCarcinoma, Pancreatic DuctalXenograft Model Antitumor AssaysCell Line, TumorMiceReceptor, Fibroblast Growth Factor, Type 4Hepatocyte Nuclear Factor 1-alpha

Keywords

Gene knockdownMetastasisCancer researchHNF1ADownregulation and upregulationBiologyPancreatic cancerIn vivoMedicineCancerInternal medicineCell cultureGeneGeneticsPancreatic Ductal AdenocarcinomaFgfr4PdacFgfr4 InhibitorsResearchXenograft Model Antitumor AssaysPancreatic NeoplasmsGene Expression Regulation, NeoplasticMiceDisease Models, AnimalCell MovementCell Line, TumorHumansAnimalsReceptor, Fibroblast Growth Factor, Type 4Hepatocyte Nuclear Factor 1-alphaNeoplasm MetastasisCarcinoma, Pancreatic Ductal

Additional file 1 of Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma

10.6084/m9.figshare.29671167.v1figshare

Additional file 1 of Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma

10.6084/m9.figshare.29671167figshare

Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma

FAIR Checklist

Authors (12)

Funding (13 grants)

Impact

Open Access

Topics

Linked Datasets (2)

Annotations (Europe PMC)