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Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B

Cell Communication and Signaling(2024)10.1186/s12964-024-01912-3Source: DataRank Database

Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B is a research paper published in Cell Communication and Signaling (2024). On theSindex it has a DataRank of 0. It has been cited 12 times.

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Open Access12 citations

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Enrichment:Funding (6 grants)Impact (FWCI 1.92)OA: goldTopics (65)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Mehwish Khan,Christine Powell,Samantha Johnson ORCID,Brayden C. Rennels,Raya I. Boyd ORCID

Live enrichment

PubMed:39482699 PMC:PMC11529429 OpenAlex:https://openalex.org/W4403941560

National Institutes of Health

Grant: T32ES007326

National Institutes of Health

Grant: CA211875

U.S. Department of Defense

Grant: W81XWH2110903

NCI NIH HHS

Grant: R01 CA211875

National Institutes of Health

Grant: 5T32ES007326-25

Research Training Program in Toxicology and Environmental Health

National Institutes of Health

Grant: 5R01CA211875-05

DNA Methylation Inhibitor Therapy for Testicular Cancer

FWCI

1.92

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://biosignaling.biomedcentral.com/counter/pdf/10.1186/s12964-024-01912-3

publisherhttps://biosignaling.biomedcentral.com/counter/pdf/10.1186/s12964-024-01912-3

publisherhttps://link.springer.com/content/pdf/10.1186/s12964-024-01912-3.pdf

publisherhttps://link.springer.com/article/10.1186/s12964-024-01912-3/fulltext.html

journalhttps://doi.org/10.1186/s12964-024-01912-3

Fields of Study

Epigenetics and DNA MethylationTesticular diseases and treatmentsHistone Deacetylase Inhibitors Research03 medical and health sciences0302 clinical medicine

MeSH Terms

AnimalsAntineoplastic AgentsBenzazepinesCisplatinHumansMaleNeoplasms, Germ Cell and EmbryonalNuclear ProteinsPyrimidinesTesticular NeoplasmsGene Expression Regulation, NeoplasticDrug Resistance, NeoplasmCell Line, TumorMiceHistone DemethylasesJumonji Domain-Containing Histone DemethylasesPolycomb-Group Proteins

Keywords

CisplatinCancer researchEpigeneticsChromodomainBiologyChromatinDemethylaseChromatin remodelingDecitabineGeneticsDNA methylationGeneChemotherapyGene expressionTesticular CancerPolycombPreclinicalTranscriptomicsChemotherapy ResistanceGsk-126Gsk-j4MaleJumonji Domain-Containing Histone DemethylasesPolycomb-Group ProteinsAntineoplastic AgentsArticleMiceTesticular NeoplasmsCell Line, TumorHumansAnimalsHistone DemethylasesQH573-671ResearchRNuclear ProteinsNeoplasms, Germ Cell and EmbryonalBenzazepinesGene Expression Regulation, NeoplasticPyrimidinesDrug Resistance, NeoplasmMedicineCytology

Sustainable Development Goals

SDG 0: Good health and well-being

Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B

FAIR Checklist

Authors (14)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)