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FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor

Journal of Translational Medicine(2021)10.1186/s12967-021-02754-0Source: DataRank Database

FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor is a research paper published in Journal of Translational Medicine (2021). On theSindex it has a DataRank of 0.584. It has been cited 10 times, with 10 citing works in its 1-hop citation network.

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0.584DataRank · unranked

Scored on demand from live citation data

Open Access10 citations · 10 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.75)OA: goldTopics (73)Linked Datasets (6)DataCite Reuse (6)IDs (PubMed, OpenAlex)SDGs (3)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 62%Citation Network 38%

Base Score Contribution

0.360

From this paper's citation signal

Citation Network Contribution

0.225

From 7 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 10 citers.

The Oncogenic FOXL2 C134W Mutation Is a Key Driver of Granulosa Cell Tumors
Cancer Research202224 citations39 referencesContributes 0.083
The Molecular Landscape of 227 Adult Granulosa Cell Tumors of the Ovary: Insights into the Progression from Primary to Recurrence
Laboratory Investigation202415 citations43 referencesContributes 0.064
Phase II clinical trial assessing the efficacy of enzalutamide in advanced non-resectable granulosa cell ovarian tumors: The GREKO III study (GETHI2016–01)
Gynecologic Oncology20244 citations44 referencesContributes 0.037
Forkhead box L2 is a target of miR‐133b and plays an important role in the pathogenesis of non‐small cell lung cancer
Cancer Medicine20237 citations65 referencesContributes 0.032
Open-label phase II clinical trial of orteronel (TAK-700) in metastatic or advanced non-resectable granulosa cell ovarian tumors: the Greko II study (GETHI2013-01)
Clinical & Translational Oncology20241 citations35 referencesContributes 0.020

Authors (6)

Paola Benaglio,Francesca Mulas,Martina Belli ORCID,Dwayne G. Stupack ORCID,Shunichi Shimasaki ORCID

Live enrichment

PubMed:33639972 OpenAlex:https://openalex.org/W3135412749

National Cancer Institute

Grant: R01CA244182

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Grant: P50HD012303

University of California, San Diego

Grant: RPR378B

National Institutes of Health

Grant: 5R01CA244182-03

FOXL2 in Adult Granulosa Cell Tumorigenesis

National Institutes of Health

Grant: 3P50HD012303-13S1

CONTROL OF THE HYPOTHALAMIC-HYPOPHYSEAL-OVARIAN SYSTEM

FWCI

0.75

Citation Percentile

0.7%

Citation Trend

2021

2022

2023

2024

goldLicense: cc-by

journalhttps://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-021-02754-0

publisherhttps://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-021-02754-0

publisherhttp://link.springer.com/content/pdf/10.1186/s12967-021-02754-0.pdf

publisherhttp://link.springer.com/article/10.1186/s12967-021-02754-0/fulltext.html

journalhttps://doi.org/10.1186/s12967-021-02754-0

Fields of Study

FOXO transcription factor regulationCancer-related molecular mechanisms researchCancer Mechanisms and Therapy0301 basic medicine03 medical and health sciences0303 health sciencesAdultCell Line, TumorDNA HelicasesFemaleForkhead Box Protein L2Forkhead Box Protein O1Forkhead Transcription FactorsGranulosa Cell TumorHumansMutationNuclear ProteinsOvarian NeoplasmsSmad3 ProteinTranscription FactorsTranscriptome

MeSH Terms

Forkhead Box Protein O1Forkhead Box Protein L2AdultDNA HelicasesFemaleGranulosa Cell TumorHumansMutationNuclear ProteinsOvarian NeoplasmsTranscription FactorsCell Line, TumorForkhead Transcription FactorsSmad3 ProteinTranscriptome

Keywords

TranscriptomeFOXO1Granulosa cellCancer researchComputational biologyMedicineBioinformaticsComputer scienceBiologyCell biologyInternal medicineOvarySignal transductionGene expressionGeneGeneticsAdultForkhead Box Protein L2FOXL2SMAD3Cell Line, TumorHumansSmad3 ProteinGranulosa Cell TumorOvarian NeoplasmsForkhead Box Protein O1ResearchRDNA HelicasesNuclear ProteinsForkhead Transcription FactorsMutationFemaleRNA-seqAdult granulosa cell tumorHGrC1Transcription Factors

Sustainable Development Goals

SDG 2: 2. Zero hungerSDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor

10.6084/m9.figshare.14131182.v1figshare

Additional file 1 of FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor

10.6084/m9.figshare.14131182figshare

Additional file 2 of FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor

10.6084/m9.figshare.14131185.v1figshare

Additional file 2 of FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor

10.6084/m9.figshare.14131185figshare

FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor

10.6084/m9.figshare.c.5321643.v1figshare