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TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

Journal of Neuroinflammation(2021)10.1186/s12974-021-02087-1Source: DataRank Database

TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats is a research paper published in Journal of Neuroinflammation (2021). On theSindex it has a DataRank of 0. It has been cited 47 times.

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Enrichment:Funding (7 grants)Impact (FWCI 2.67)OA: goldTopics (70)Linked Datasets (8)DataCite Reuse (8)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

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Context only (not used in score)

Findable (2/2)

Has DOI
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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (8)

Nathanael Matei ORCID,Devin W. McBride ORCID,Xu Yang ORCID,Zhenhua Zhou ORCID,Jiping Tang ORCID

Live enrichment

PubMed:33531049 PMC:PMC7856773 OpenAlex:https://openalex.org/W3114024317

Foundation for the National Institutes of Health

Grant: NS081740 and NS082184

National Natural Science Foundation of China

Grant: 81671143

Zhejiang Province Public Welfare Technology Application Research Project

Grant: LGF21H090013

NINDS NIH HHS

Grant: R01 NS081740

NINDS NIH HHS

Grant: P01 NS082184

National Institutes of Health

Grant: 5R01NS081740-05

Neurovascular Protection for Early Brain Injury after SAH

National Institutes of Health

Grant: 1P01NS082184-01A1

Neurological and Neurobehavioral Function Evaluation Core

FWCI

2.67

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://jneuroinflammation.biomedcentral.com/track/pdf/10.1186/s12974-021-02087-1

publisherhttps://jneuroinflammation.biomedcentral.com/track/pdf/10.1186/s12974-021-02087-1

publisherhttp://link.springer.com/content/pdf/10.1186/s12974-021-02087-1.pdf

publisherhttp://link.springer.com/article/10.1186/s12974-021-02087-1/fulltext.html

journalhttps://doi.org/10.1186/s12974-021-02087-1

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsImmune Response and InflammationDrug Transport and Resistance Mechanisms0301 basic medicine03 medical and health sciences0303 health sciencesAdministration, IntranasalAnimalsBrainCaspase 8Cholic AcidsInfarction, Middle Cerebral ArteryInflammation MediatorsInjections, IntraventricularMaleNLR Family, Pyrin Domain-Containing 3 ProteinRNA, Small InterferingRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledUbiquitin-Protein Ligases

MeSH Terms

NLR Family, Pyrin Domain-Containing 3 ProteinAdministration, IntranasalAnimalsBrainCholic AcidsInjections, IntraventricularMaleRats, Sprague-DawleyInflammation MediatorsInfarction, Middle Cerebral ArteryRNA, Small InterferingReceptors, G-Protein-CoupledUbiquitin-Protein LigasesRatsCaspase 8

Keywords

NeuroinflammationG protein-coupled bile acid receptorMedicinePharmacologyPyrin domainAgonistReceptorInflammationInflammasomeInternal medicinemiddle cerebral artery occlusionneuroprotectionTgr5Early Brain InjuryMaleUbiquitin-Protein Ligases610Receptors, G-Protein-CoupledRats, Sprague-DawleyNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsRNA, Small InterferingRC346-429Administration, IntranasalInjections, IntraventricularCaspase 8ResearchBrainCholic AcidsInfarction, Middle Cerebral Artery620RatsNeurology. Diseases of the nervous systemInflammation Mediators

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 4 of TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

10.6084/m9.figshare.13698342.v1figshare

Additional file 4 of TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

10.6084/m9.figshare.13698342figshare

Additional file 3 of TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

10.6084/m9.figshare.13698339.v1figshare

Additional file 2 of TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

10.6084/m9.figshare.13698336figshare

Additional file 2 of TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

10.6084/m9.figshare.13698336.v1figshare

Additional file 1 of TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

10.6084/m9.figshare.13698333.v1figshare

Additional file 3 of TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

10.6084/m9.figshare.13698339figshare

Additional file 1 of TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

10.6084/m9.figshare.13698333figshare

TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

FAIR Checklist

Authors (8)

Funding (7 grants)

Impact

Open Access

Topics

Linked Datasets (8)

Annotations (Europe PMC)