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Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration

Journal of Neuroinflammation(2025)10.1186/s12974-025-03420-8Source: DataRank Database

Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration is a research paper published in Journal of Neuroinflammation (2025). On theSindex it has a DataRank of 0. It has been cited 20 times.

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Open Access20 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 9.13)OA: goldTopics (59)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Fuyao Li ORCID,Shuwen Zhang ORCID,Yixing Chen ORCID,Tadafumi C. Ikezu ORCID,Zonghua Li ORCID

Live enrichment

PubMed:40122810 PMC:PMC11931752 OpenAlex:https://openalex.org/W4408747406

National Institutes of Health

Grant: R01AG66395

NIA NIH HHS

Grant: R01 AG066395

NIA NIH HHS

Grant: RF1 AG056130

National Institutes of Health

Grant: 2RF1AG056130-02

Molecular pathobiology of soluble TREM2 in Alzheimer's disease

National Institutes of Health

Grant: 1R13AG013039-01

1995 SUMMER INSTITUTE IN GERIATRIC MEDICINE

National Institutes of Health

Grant: 5R01AG066395-05

TREM2-mediated microglial dynamic function in Alzheimer disease

National Institutes of Health

Grant: 1U19AG069701-01

Biology and pathobiology of apoE in aging and Alzheimer's disease

National Institutes of Health

Grant: 1R01AG087165-01

Elucidating the Pathomechanisms of APOE4 in Lewy Body Dementia

Cure Alzheimer’s Fund

BrightFocus Foundation

FWCI

9.13

Citation Percentile

1.0%

Citation Trend

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1186/s12974-025-03420-8

publisherhttps://doi.org/10.1186/s12974-025-03420-8

publisherhttps://link.springer.com/content/pdf/10.1186/s12974-025-03420-8.pdf

publisherhttps://link.springer.com/article/10.1186/s12974-025-03420-8/fulltext.html

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40122810

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsInflammation biomarkers and pathwaysNeurological Disease Mechanisms and Treatments03 medical and health sciences0302 clinical medicineMicrogliaReceptors, ImmunologicAnimalsMembrane GlycoproteinsMiceHumansMice, TransgenicTauopathiestau ProteinsDisease Models, AnimalNerve Degeneration

MeSH Terms

Alzheimer DiseaseAnimalsDisease Models, AnimalHumansMembrane GlycoproteinsMice, TransgenicNerve DegenerationReceptors, Immunologictau ProteinsMicrogliaTauopathiesMice

Keywords

TREM2MicrogliaNeurodegenerationNeuroscienceNeurologyNeuroinflammationMedicineNeuroimmunologyPathologyInflammationBiologyImmunologyDiseaseCentral nervous systemAlzheimer’s diseaseTranscriptomicsTau PathologyR47h VariantMembrane GlycoproteinsResearchMice, Transgenictau ProteinsMiceDisease Models, AnimalTauopathiesNerve DegenerationAnimalsHumansNeurology. Diseases of the nervous systemReceptors, ImmunologicRC346-429

Sustainable Development Goals

SDG 0: Zero hunger

Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration

FAIR Checklist

Authors (13)

Funding (10 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)