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Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands

Molecular Neurodegeneration(2025)10.1186/s13024-024-00795-9Source: DataRank Database

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands is a research paper published in Molecular Neurodegeneration (2025). On theSindex it has a DataRank of 0. It has been cited 38 times.

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Open Access38 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 13.31)OA: goldTopics (48)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (12)

Joshua R. Wydra,Rory A. Greer ORCID,Cynthia Zhi,David A. Price ORCID,Jordyn D. Svoboda

Live enrichment

PubMed:39789647 OpenAlex:https://openalex.org/W4406199523

Alzheimer’s Association

Grant: AARG-16-441560

Alzheimer’s Association

Grant: ZEN-25-1269507

BrightFocus Foundation

Grant: A2022032S

Burroughs Wellcome Fund

Grant: CAMS 1014685

National Heart, Lung, and Blood Institute

Grant: R01HL152245

National Heart, Lung, and Blood Institute

Grant: R01HL170198

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Grant: R01AI159678

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Grant: R01AI169850

National Institutes of Health

Grant: 5R01HL170198-02

TMEM16A in human airway disease

National Institutes of Health

Grant: 5R01AG081228-02

Drugs repositioning to target TREM2 in Alzheimer disease

National Institutes of Health

Grant: 1R01HL152245-01A1

Non-Classical Cytokine Secretion in Chronic Airway Disease

National Institutes of Health

Grant: 1R01AI169850-01A1

Characterizing the role of LDL related receptor 1 (Lrp1) as host entry factor for multiple bunyaviruses

National Institutes of Health

Grant: 5R01AG068395-04

TREM2-endogenous ligand interactions in Alzheimer disease

National Institutes of Health

Grant: 5R01AI159678-02

Mechanisms of Host Response Modulation by RSV Non-Structural Proteins

NIA NIH HHS

Grant: R01 AG081228

NIA NIH HHS

Grant: R01 AG068395

FWCI

13.31

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

goldLicense: cc-by

journalhttps://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s13024-024-00795-9

publisherhttps://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s13024-024-00795-9

publisherhttps://link.springer.com/content/pdf/10.1186/s13024-024-00795-9.pdf

publisherhttps://link.springer.com/article/10.1186/s13024-024-00795-9/fulltext.html

journalhttps://doi.org/10.1186/s13024-024-00795-9

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsImmune Response and InflammationS100 Proteins and Annexins0301 basic medicine03 medical and health sciencesAlzheimer DiseaseMembrane GlycoproteinsReceptors, ImmunologicHumansLigandsProtein BindingBinding Sites

MeSH Terms

Alzheimer DiseaseBinding SitesHumansLigandsMembrane GlycoproteinsProtein BindingReceptors, Immunologic

Keywords

TREM2Binding siteChemistryPlasma protein bindingMicrogliaLigand (biochemistry)BiologyReceptorComputational biologyBiochemistryImmunologyMembrane GlycoproteinsBinding SitesTDP-43Complement C1qRC952-954.6LigandsapoEIL-34GeriatricsAlzheimer DiseaseHumansNeurology. Diseases of the nervous systemReceptors, ImmunologicRC346-429Research ArticleProtein BindingAlzheimer’s diseaseAmyloid beta

Additional file 1 of Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands

10.6084/m9.figshare.28180833.v1figshare

Additional file 1 of Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands

10.6084/m9.figshare.28180833figshare