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Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

Genome Medicine(2021)10.1186/s13073-021-00939-2Source: DataRank Database

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes is a research paper published in Genome Medicine (2021). On theSindex it has a DataRank of 0. It has been cited 46 times.

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Enrichment:Funding (44 grants)OA: goldTopics (121)Linked Datasets (12)DataCite Reuse (12)IDs (PubMed)SDGs (2)

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Authors (21)

Zong Miao ORCID,Caroline Comenho,Sandhya Rajkumar ORCID,Amogha Koka,Seung Hyuk Lee ORCID

Live enrichment

PubMed:34340684

National Heart, Lung, and Blood Institute

Grant: HL-095056

National Heart, Lung, and Blood Institute

Grant: HL-28481

National Heart, Lung, and Blood Institute

Grant: F31-HL142180

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: U01 DK105561

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: F31 DK118865-02

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: DK072193

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: DK093757

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: DK062370

National Cancer Institute

Grant: T32LM012424

American Heart Association

Grant: 19PRE34430112

National Institute of General Medical Sciences

Grant: R25GM055052

National Institute of General Medical Sciences

Grant: GM-0532275

Howard Hughes Medical Institute

Grant: Gilliam Fellowhip

National Human Genome Research Institute

Grant: HG-009120

National Human Genome Research Institute

Grant: Z01HG000024

Academy of Finland

Grant: 316458

Aberrant RNA splicing in obesity

Academy of Finland

Grant: 138006

Liver, lipid and drug metabolism in obesity and after obesity surgery

National Institutes of Health

Grant: 5T32LM012424-03

Biomedical Big Data Training Grant

National Institutes of Health

Grant: 5P01HL028481-09

MOLECULAR GENETIC APPROACHES IN ATHEROSCLEROSIS RESEARCH

National Institutes of Health

Grant: 1Z01HG000024-09

Genetic analysis of type II diabetes in Finnish populati

National Institutes of Health

Grant: 5F31DK118865-02

Investigation of chromosomal interactions and obesogenic gene regulatory networks in adipose

National Institutes of Health

Grant: 2R25GM055052-18

UCLA Maximizing Student Development (MSD) Program

National Institutes of Health

Grant: 1R01DK062370-01A1

Identifying Genes for Type 2 Diabetes: FUSION

National Institutes of Health

Grant: 5R01DK072193-16

Targeted Genetic Analysis of T2D and Quantitative Traits

National Institutes of Health

Grant: 3U01DK105561-03S1

Functional genetic variants for type 2 diabetes

National Institutes of Health

Grant: 1Z01HG000024-14

Genetic analysis of type II diabetes in Finnish population

National Institutes of Health

Grant: 5F31HL142180-02

Integrating functional genomics in primary human adipocytes to investigate gene regulatory circuitry for obesogenic cardiovascular traits

National Institutes of Health

Grant: 5R01HG009120-04

Integrative approaches for mapping the genetic risk of complex traits

National Institutes of Health

Grant: 3R01DK093757-05S1

Genetic epidemiology of rare and regulatory variants for metabolic traits

National Institutes of Health

Grant: 5R01HL095056-04

Genetics of high serum triglycerides and related metabolic traits in Mexicans

NIDDK NIH HHS

Grant: R01 DK093757

NIDDK NIH HHS

Grant: R56 DK062370

Medical Research Council

Grant: MC_QA137853

NIDDK NIH HHS

Grant: R01 DK117850

NHLBI NIH HHS

Grant: P01 HL028481

NIDDK NIH HHS

Grant: R01 DK062370

NHLBI NIH HHS

Grant: F31 HL142180

NIDDK NIH HHS

Grant: U01 DK062370

NHGRI NIH HHS

Grant: R01 HG009120

Medical Research Council

Grant: MC_PC_17228

NIDDK NIH HHS

Grant: F31 DK118865

NHGRI NIH HHS

Grant: R01 HG010505

NIDDK NIH HHS

Grant: R01 DK072193

NHLBI NIH HHS

Grant: R01 HL095056

goldLicense: cc-by

publisherhttps://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-021-00939-2

publisherhttps://link.springer.com/content/pdf/10.1186/s13073-021-00939-2.pdf

publisherhttps://link.springer.com/article/10.1186/s13073-021-00939-2/fulltext.html

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8327600

repositoryhttp://hdl.handle.net/10138/334906

Fields of Study

0301 basic medicine03 medical and health sciencesAdipocytesAdipose TissueAdiposityAgedAlgorithmsBiomarkersBody Mass IndexCells, CulturedComputational BiologyDiabetes Mellitus, Type 2Disease SusceptibilityGene Expression ProfilingGene Expression RegulationGene Knockdown TechniquesGene Regulatory NetworksGenome-Wide Association StudyHigh-Throughput Nucleotide SequencingHumansLod ScoreMaleMiddle AgedObesity, AbdominalT-Box Domain ProteinsTrans-ActivatorsWaist-Hip Ratio

MeSH Terms

AdipocytesAdipose TissueAdiposityAgedAlgorithmsBiomarkersBody Mass IndexCells, CulturedComputational BiologyDiabetes Mellitus, Type 2Disease SusceptibilityGene Expression ProfilingGene Expression RegulationGene Knockdown TechniquesGene Regulatory NetworksGenome-Wide Association StudyHigh-Throughput Nucleotide SequencingHumansLod ScoreMaleMiddle AgedObesity, AbdominalT-Box Domain ProteinsTrans-ActivatorsWaist-Hip Ratio

Keywords

MaleLOCIWaist-hip ratio adjusted for body mass indexQH426-470Master transcription factorBody Mass IndexELEMENTSAdipocytes2.1 Biological and endogenous factorsAMINO-ACIDSGene Regulatory NetworksRNA-SEQAetiologyType 2 diabetes (T2D)Cells, CulturedAdiposityCulturedDiabetesRHigh-Throughput Nucleotide SequencingType 2 diabetesMiddle AgedGeneral medicine, internal medicine and other clinical medicineAdipose TissueGenetics, developmental biology, physiologyGene Knockdown TechniquesMedicineDisease SusceptibilityType 2AlgorithmsBiotechnologyEXPRESSIONCells1.1 Normal biological development and functioningClinical SciencesPOWER610Trans regulation of genesPolygenic risk scoreUnderpinning researchDiabetes MellitusTranscriptional regulation of abdominal obesityGeneticsHumansAbdominalObesityGENOME-WIDE ASSOCIATIONMetabolic and endocrineNutritionAgedWaist-Hip RatioPreventionResearchGene Expression ProfilingHuman GenomeEstados Unidos de América / United StatesWaist-hip ratio adjusted for body mass index (WHRadjBMI)Computational BiologyFAT DISTRIBUTIONPolygenic risk score (PRS)Diabetes Mellitus, Type 2Gene Expression RegulationTrans-ActivatorsMEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::BIOQUÍMICA::GENÉTICA BIOQUÍMICAWEIGHTLod ScoreT-Box Domain ProteinsBiomarkersGenome-Wide Association Study

Sustainable Development Goals

SDG 2: 2. Zero hungerSDG 3: 3. Good health

Additional file 1 of Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

10.6084/m9.figshare.15094867.v1figshare

Additional file 1 of Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

10.6084/m9.figshare.15094867figshare

Additional file 2 of Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

10.6084/m9.figshare.15094873.v1figshare

Additional file 2 of Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

10.6084/m9.figshare.15094873figshare

Additional file 1 of Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

10.6084/m9.figshare.25123924.v1figshare

Additional file 1 of Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

10.6084/m9.figshare.25123924figshare

Additional file 2 of Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

10.6084/m9.figshare.25124079.v1figshare

Additional file 2 of Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

10.6084/m9.figshare.25124079figshare

Additional file 3 of Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

10.6084/m9.figshare.26675165figshare

Additional file 3 of Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

10.6084/m9.figshare.26675165.v1figshare

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

10.6084/m9.figshare.c.5539990.v1figshare

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

10.6084/m9.figshare.c.5539990figshare