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Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer

Genome Medicine(2024)10.1186/s13073-024-01407-3Source: DataRank Database

Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer is a research paper published in Genome Medicine (2024). On theSindex it has a DataRank of 0.678. It has been cited 29 times, with 27 citing works in its 1-hop citation network.

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0.678DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access29 citations · 27 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE240112

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (1 grants)Impact (FWCI 4.70)OA: goldTopics (65)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 75%Citation Network 25%

Base Score Contribution

0.510

From this paper's citation signal

Citation Network Contribution

0.167

From 13 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 27 citers.

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Targeting Resistance Pathways in Breast Cancer Through Precision Oncology: Nanotechnology and Immune Modulation Approaches
Biomedicines20257 citations145 referencesContributes 0.014

Authors (10)

Aigbe G. Ohihoin,Tianxiang Liu ORCID,Lavanya Choppavarapu,Bakhtiyor Nosirov ORCID,Qianben Wang ORCID

Live enrichment

PubMed:39558215 PMC:PMC11572372 OpenAlex:https://openalex.org/W4404487879

National Institutes of Health

Grant: 5R01GM114142-09

Omics analysis of three-dimensional transcriptional regulation

FWCI

4.70

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://genomemedicine.biomedcentral.com/counter/pdf/10.1186/s13073-024-01407-3

publisherhttps://genomemedicine.biomedcentral.com/counter/pdf/10.1186/s13073-024-01407-3

publisherhttps://link.springer.com/content/pdf/10.1186/s13073-024-01407-3.pdf

publisherhttps://link.springer.com/article/10.1186/s13073-024-01407-3/fulltext.html

journalhttps://doi.org/10.1186/s13073-024-01407-3

Fields of Study

Single-cell and spatial transcriptomicsCancer Cells and MetastasisCancer Immunotherapy and Biomarkers0301 basic medicine0303 health sciences03 medical and health sciencesHumansTamoxifenSingle-Cell AnalysisBreast NeoplasmsFemaleDrug Resistance, NeoplasmEpigenesis, GeneticGene Expression Regulation, NeoplasticGenetic HeterogeneityTranscriptomeAntineoplastic Agents, HormonalBone Morphogenetic Protein 7Cell Line, Tumor

MeSH Terms

Breast NeoplasmsFemaleHumansTamoxifenGene Expression Regulation, NeoplasticGenetic HeterogeneityAntineoplastic Agents, HormonalDrug Resistance, NeoplasmEpigenesis, GeneticCell Line, TumorBone Morphogenetic Protein 7Single-Cell AnalysisTranscriptome

Keywords

Breast cancerBiologyCancer researchCancerChromatinTranscriptomeGene signatureCellEpigeneticsSingle-cell analysisTamoxifenCell typeTranscription factorComputational biologyGeneticsGeneGene expressionBreast Tumor HeterogeneityEpigenetic-regulated Cancer Cell StatesAntineoplastic Agents, HormonalResearchBone Morphogenetic Protein 7RBreast NeoplasmsQH426-470Epigenesis, GeneticGene Expression Regulation, NeoplasticGenetic HeterogeneityDrug Resistance, NeoplasmCell Line, TumorMedicineHumansFemale

Sustainable Development Goals

SDG 0: Good health and well-being