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DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

Acta Neuropathologica Communications(2020)10.1186/s40478-019-0874-4Source: DataRank Database

DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations is a research paper published in Acta Neuropathologica Communications (2020). On theSindex it has a DataRank of 0. It has been cited 100 times.

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Enrichment:Funding (7 grants)OA: goldTopics (52)Linked Datasets (4)DataCite Reuse (4)IDs (PubMed, PMC)SDGs (1)

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Authors (4)

Ye Eun Jeong ORCID,Margaret Wong,Lee J. Martin ORCID,Byung‐Woo Kim ORCID

Live enrichment

PubMed:32005289 PMC:PMC6995159

National Institutes of Health

Grant: NS079348

NINDS NIH HHS

Grant: R01 NS079348

National Institutes of Health

Grant: 5R01NS065895-04

Skeletal Muscle Mechanisms of Disease in ALS

National Institutes of Health

Grant: 5R01NS052098-03

DNA Damage/Repair and Cell Death

National Institutes of Health

Grant: 5R01NS034100-03

MOTOR NEURON DEATH AND GLUTAMATE RECEPTORS

National Institutes of Health

Grant: 1R01NS079348-01A1

Epigenetic Regulation of Neuronal Cell Death

National Institutes of Health

Grant: 1R01AG016282-01A1

MECHANISMS OF NEURONAL APOPTOSIS IN VIVO

goldLicense: cc-by

publisherhttps://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0874-4.pdf

publisherhttp://link.springer.com/content/pdf/10.1186/s40478-019-0874-4.pdf

publisherhttp://link.springer.com/article/10.1186/s40478-019-0874-4/fulltext.html

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/6995159

repositoryhttps://doaj.org/article/59ce78a5a0194c4f9fedd15673e88f4c

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

Motor CortexSpinal CordNeurogliaMotor NeuronsHumansAmyotrophic Lateral SclerosisDNA DamageProto-Oncogene Proteins c-ablCell DeathDNA RepairUp-RegulationMutationGenes, BRCA1AdultAgedAged, 80 and overMiddle AgedFemaleMaleInduced Pluripotent Stem CellsSuperoxide Dismutase-1

Keywords

ApoptosisMotor cortexp53Motor neuronATMBase Excision RepairDna N-glycosylaseAdultMaleDNA RepairInduced Pluripotent Stem CellsGenes, BRCA1Superoxide Dismutase-1HumansRC346-429Proto-Oncogene Proteins c-ablAgedAged, 80 and overMotor NeuronsCell DeathResearchAmyotrophic Lateral SclerosisMiddle AgedSpinal CordMutationFemaleNeurology. Diseases of the nervous systemNeurogliaDNA Damage

Sustainable Development Goals

SDG 3: 3. Good health

Additional file 1 of DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

10.6084/m9.figshare.11784972.v1figshare

Additional file 1 of DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

10.6084/m9.figshare.11784972figshare

Additional file 2 of DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

10.6084/m9.figshare.11784981.v1figshare

Additional file 2 of DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

10.6084/m9.figshare.11784981figshare