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Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

Acta Neuropathologica Communications(2021)10.1186/s40478-021-01226-2Source: DataRank Database

Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study is a research paper published in Acta Neuropathologica Communications (2021). On theSindex it has a DataRank of 1.2. It has been cited 53 times, with 41 citing works in its 1-hop citation network.

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1.2DataRank · unranked

Scored on demand from live citation data

53 citations · 41 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 3.09)OA: goldTopics (68)Linked Datasets (22)DataCite Reuse (22)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (0/2)

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 49%Citation Network 51%

Base Score Contribution

0.598

From this paper's citation signal

Citation Network Contribution

0.628

From 31 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 41 citers.

High plasma complement C4 levels as a novel predictor of clinical outcome in intracerebral hemorrhage
Frontiers in Aging Neuroscience202312 citations39 referencesContributes 0.066
Repeated mild traumatic brain injury in mice elicits long term innate immune cell alterations in blood, spleen, and brain
Journal of Neuroimmunology202311 citations45 referencesContributes 0.055
Focal lesion size poorly correlates with motor function after experimental traumatic brain injury in mice
PLoS ONE20229 citations46 referencesContributes 0.050
Knockdown of membrane-bound complement regulatory proteins suppresses colon cancer growth in mice through inducing tumor cell apoptosis
International Immunopharmacology20229 citations48 referencesContributes 0.048
Bioinformatics analysis of the mechanisms of traumatic brain injury-associated dementia based on the competing endogenous RNA
Psychopharmacology20243 citations38 referencesContributes 0.036

Authors (4)

Mamatha Mandava ORCID,Silvia Guglietta ORCID,Stephen Tomlinson ORCID,Amer Toutonji

Live enrichment

PubMed:34281628 PMC:PMC8287781 OpenAlex:https://openalex.org/W3183938588

U.S. Department of Veterans Affairs

Grant: 1BX004256

U.S. Department of Veterans Affairs

Grant: 1RX001141

U.S. Department of Veterans Affairs

Grant: IK6BX005235

BLRD VA

Grant: I01 BX004256

RRD VA

Grant: I01 RX001141

National Institutes of Health

Grant: 1IK6BX005235-01

BLR&D Research Career Scientist Award Application for Dr. Stephen Tomlinson

FWCI

3.09

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1186/s40478-021-01226-2

publisherhttps://doi.org/10.1186/s40478-021-01226-2

publisherhttps://link.springer.com/content/pdf/10.1186/s40478-021-01226-2.pdf

publisherhttps://link.springer.com/article/10.1186/s40478-021-01226-2/fulltext.html

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34281628

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular DisturbancesNeonatal and fetal brain pathology0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsBrainBrain Injuries, TraumaticBrain Injury, ChronicComplement ActivationComplement C2Complement C3Complement C4Complement Inactivating AgentsGene Expression ProfilingMiceNeuroinflammatory DiseasesRecombinant Fusion ProteinsTranscriptome

MeSH Terms

Brain Injuries, TraumaticNeuroinflammatory DiseasesAnimalsBrainComplement ActivationComplement C2Complement C3Complement C4Recombinant Fusion ProteinsBrain Injury, ChronicGene Expression ProfilingComplement Inactivating AgentsMiceTranscriptome

Keywords

NeuroinflammationComplement systemNeuroprotectionTraumatic brain injuryDownregulation and upregulationAstrogliosisInflammationMedicineTranscriptomeNeuroscienceGene expressionImmunologyImmune systemBiologyCentral nervous systemGeneComplement InhibitionNanostringRecombinant Fusion ProteinsMiceBrain Injuries, TraumaticBrain Injury, ChronicAnimalsRC346-429Complement ActivationResearchGene Expression ProfilingBrainComplement C4Complement C3Complement C2Complement Inactivating AgentsNeuroinflammatory DiseasesNeurology. Diseases of the nervous system

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 3 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 3 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 4 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 4 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 1 of Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes

10.6084/m9.figshare.23505337.v1figshare

Additional file 1 of Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes

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Additional file 1 of Bi-directional neuro-immune dysfunction after chronic experimental brain injury

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Additional file 1 of Bi-directional neuro-immune dysfunction after chronic experimental brain injury

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Additional file 1 of Complement propagates visual system pathology following traumatic brain injury

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Additional file 1 of Complement propagates visual system pathology following traumatic brain injury

10.6084/m9.figshare.25632946.v1figshare

Additional file 7 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 7 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 6 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 5 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 5 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 6 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

10.6084/m9.figshare.15020663figshare

Additional file 2 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 2 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

10.6084/m9.figshare.15020651.v1figshare

Additional file 1 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

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Additional file 1 of Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

10.6084/m9.figshare.15020648.v1figshare

Related Papers (4)

Comparison of T1-Post and FLAIR-Post MRI for identification of traumatic meningeal enhancement in traumatic brain injury patients

N/A

0.651DataRank · unranked

PLoS ONE(2020)

co-cited

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Biological Psychiatry(2021)

co-cited

10.1016/j.biopsych.2021.05.025

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eLife(2022)

co-cited

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Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (4)

Funding (6 grants)

Impact

Open Access

Topics

Linked Datasets (22)

Annotations (Europe PMC)

Related Papers (4)