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Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice

Acta Neuropathologica Communications(2021)10.1186/s40478-021-01231-5Source: DataRank Database

Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice is a research paper published in Acta Neuropathologica Communications (2021). On theSindex it has a DataRank of 0.524. It has been cited 32 times.

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0.524DataRank · unranked

Scored on demand from live citation data

Open Access32 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 1.94)OA: goldTopics (95)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.524

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (6)

Shaowu Cheng ORCID,Rui Zhong ORCID,David A. Bennett ORCID,Martin O. Bergö ORCID,Ling Li ORCID

Live enrichment

PubMed:34315531 PMC:PMC8314463 OpenAlex:https://openalex.org/W3185610770

National Institute on Aging

Grant: R01AG031846; RF1AG056976; RF1AG058081

National Institute on Aging

Grant: P30AG10161; R01AG15819

NIA NIH HHS

Grant: R01 AG015819

NIA NIH HHS

Grant: R01 AG031846

NIA NIH HHS

Grant: P30 AG010161

NIA NIH HHS

Grant: RF1 AG056976

NIA NIH HHS

Grant: RF1 AG058081

National Institutes of Health

Grant: 5R01AG031846-03

Protective Mechanisms of Statins in Alzheimer's Disease

National Institutes of Health

Grant: 1RF1AG056976-01

Dysregulation of Protein Prenylation in the Pathogenesis of Alzheimer's Disease

National Institutes of Health

Grant: 1P30AG010161-01

SHORT-TERM STABILITY OF CLINICAL TESTS

National Institutes of Health

Grant: 1RF1AG058081-01

HDL Mimetic Peptide-Mediated Enhancement of Neurovascular Function to Mitigate Cerebral Amyloid Angiopathy and Alzheimer's Disease

National Institutes of Health

Grant: 5R01AG015819-07

Risk Factors, Pathology, and Clinical Expressions of AD

FWCI

1.94

Citation Percentile

0.9%

Influential Citations

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-021-01231-5

GOLDhttps://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-021-01231-5

publisherhttps://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-021-01231-5

publisherhttps://link.springer.com/content/pdf/10.1186/s40478-021-01231-5.pdf

publisherhttps://link.springer.com/article/10.1186/s40478-021-01231-5/fulltext.html

Fields of Study

Alzheimer's disease research and treatmentsNuclear Receptors and SignalingProtein Tyrosine PhosphatasesMedicineBiology03 medical and health sciences0302 clinical medicineAged, 80 and overAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsBehavior, AnimalBrainCognitive DysfunctionDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesFarnesyltranstransferaseFemaleHumansMaleMechanistic Target of Rapamycin Complex 1MiceMice, KnockoutMice, TransgenicNeuronsPlaque, AmyloidPresenilin-1Protein PrenylationProto-Oncogene Proteins p21(ras)Signal Transduction

MeSH Terms

Mechanistic Target of Rapamycin Complex 1Aged, 80 and overAlzheimer DiseaseAnimalsBehavior, AnimalBrainDisease Models, AnimalFemaleHumansMaleMice, TransgenicNeuronsSignal TransductionProto-Oncogene Proteins p21(ras)Amyloid beta-Protein PrecursorProtein PrenylationMice, KnockoutExtracellular Signal-Regulated MAP KinasesFarnesyltranstransferaseMicePresenilin-1Plaque, AmyloidCognitive Dysfunction

Keywords

FarnesyltransferaseDownregulation and upregulationNeuroscienceNeuronAlzheimer's diseaseNeurologyMedicineBiologyPrenylationBiochemistryEnzymeInternal medicineGeneDiseaseCholesterolIsoprenoidsAlzheimer’s diseaseSmall GtpasesProtein PrenylationMaleMice, TransgenicPlaque, AmyloidMechanistic Target of Rapamycin Complex 1Amyloid beta-Protein PrecursorMiceAlzheimer DiseasePresenilin-1AnimalsFarnesyltranstransferaseHumansCognitive DysfunctionRC346-429Extracellular Signal-Regulated MAP KinasesAged, 80 and overMice, KnockoutNeuronsBehavior, AnimalResearchBrainDisease Models, AnimalFemaleNeurology. Diseases of the nervous system

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being