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Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Acta Neuropathologica Communications(2021)10.1186/s40478-021-01283-7Source: DataRank Database

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein is a research paper published in Acta Neuropathologica Communications (2021). On theSindex it has a DataRank of 0. It has been cited 35 times.

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Open Access35 citations

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Enrichment:Funding (8 grants)Impact (FWCI 2.61)OA: goldTopics (54)Linked Datasets (14)DataCite Reuse (14)IDs (PubMed, PMC, OpenAlex)SDGs (1)

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Findable (2/2)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (9)

Baraa Hijaz ORCID,Vijay P. Singh ORCID,Nolwazi Z. Gcwensa ORCID,Kaela Kelly ORCID,Edward S. Boyden ORCID

Live enrichment

PubMed:34749824 PMC:PMC8576889 OpenAlex:https://openalex.org/W3213563515

National Institute of Neurological Disorders and Stroke

Grant: R01NS102257

National Institute of Neurological Disorders and Stroke

Grant: R56NS117465

Michael J. Fox Foundation for Parkinson's Research

Grant: MJFF-004413

National Institute of Health

Grant: 1R01EB024261

NIBIB NIH HHS

Grant: R01 EB024261

NINDS NIH HHS

Grant: P50 NS108675

Howard Hughes Medical Institute

FWCI

2.61

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://actaneurocomms.biomedcentral.com/counter/pdf/10.1186/s40478-021-01283-7

publisherhttps://actaneurocomms.biomedcentral.com/counter/pdf/10.1186/s40478-021-01283-7

publisherhttps://link.springer.com/content/pdf/10.1186/s40478-021-01283-7.pdf

publisherhttps://link.springer.com/article/10.1186/s40478-021-01283-7/fulltext.html

journalhttps://doi.org/10.1186/s40478-021-01283-7

Fields of Study

Parkinson's Disease Mechanisms and TreatmentsBotulinum Toxin and Related Neurological DisordersNeurological disorders and treatmentsAnimalsAxonal TransportEnzyme InhibitorsFemaleHippocampusLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MiceMice, Inbred C57BLNeuronsParkinson DiseasePregnancyPrimary Cell CultureReceptors, PresynapticVesicular Glutamate Transport Protein 1alpha-Synuclein

MeSH Terms

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2AnimalsAxonal TransportEnzyme InhibitorsFemaleHippocampusMice, Inbred C57BLNeuronsParkinson DiseasePregnancyReceptors, PresynapticVesicular Glutamate Transport Protein 1Micealpha-SynucleinPrimary Cell Culture

Keywords

LRRK2NeuroscienceAxoplasmic transportAlpha-synucleinParkinson's diseaseCell biologyBiologySynaptic vesicleChemistryPathologyMedicineBiochemistryVesicleDiseaseSynapseTraffickingα-synucleinParkinson’s DiseaseAxonal TransportPresynapticExpansion Microscopy

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 1 of Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

10.6084/m9.figshare.16960348.v1figshare

Additional file 1 of Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

10.6084/m9.figshare.16960348figshare

Additional file 2 of Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

10.6084/m9.figshare.16960351.v1figshare

Additional file 2 of Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

10.6084/m9.figshare.16960351figshare

Additional file 3 of Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

10.6084/m9.figshare.16960354.v1figshare

Additional file 3 of Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

10.6084/m9.figshare.16960354figshare

Additional file 1 of Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain

10.6084/m9.figshare.26655613.v1figshare

Additional file 1 of Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain

10.6084/m9.figshare.26655613figshare

Additional file 2 of Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain

10.6084/m9.figshare.26655616.v1figshare

Additional file 2 of Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain

10.6084/m9.figshare.26655616figshare

Additional file 3 of Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain

10.6084/m9.figshare.26655619.v1figshare

Additional file 3 of Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain

10.6084/m9.figshare.26655619figshare

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

10.6084/m9.figshare.c.5698246.v1figshare

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

10.6084/m9.figshare.c.5698246figshare