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The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis

Journal of Lipid Research(2020)10.1194/jlr.ra120000895Source: DataRank Database

The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis is a research paper published in Journal of Lipid Research (2020). On theSindex it has a DataRank of 0. It has been cited 42 times.

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0DataRank · unranked

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Open Access42 citations

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Enrichment:Funding (8 grants)Impact (FWCI 3.51)OA: hybridTopics (53)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Noton K. Dutta ORCID,Valentina Guerrini ORCID,Hugh Salamon ORCID,Ken Yamaguchi ORCID,Petros C. Karakousis ORCID

Live enrichment

PubMed:32848049 PMC:PMC7707180 OpenAlex:https://openalex.org/W3080085699

National Institutes of Health

Grant: R01 AI104615

NHLBI NIH HHS

Grant: R01 HL149450

NCATS NIH HHS

Grant: UL1 TR003017

NIAID NIH HHS

Grant: UH2 AI122309

NIAID NIH HHS

Grant: K08 AI064229

New Jersey Health Foundation

Grant: PC 10-15

National Institutes of Health

Grant: UH2/3 AI122309

NIAID NIH HHS

Grant: UH3 AI122309

FWCI

3.51

Citation Percentile

0.9%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.jlr.org/article/S0022227520600232/pdf

publisherhttp://www.jlr.org/article/S0022227520600232/pdf

journalhttps://doi.org/10.1194/jlr.ra120000895

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7707180

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32848049

Fields of Study

Diet, Metabolism, and DiseasePI3K/AKT/mTOR signaling in cancerCholesterol and Lipid MetabolismSimvastatinMechanistic Target of Rapamycin Complex 1AutophagyAMP-Activated Protein KinasesCholesterolAntitubercular AgentsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsHumansMycobacterium tuberculosisAnimalsMiceMacrophages

MeSH Terms

Mechanistic Target of Rapamycin Complex 1AnimalsAntitubercular AgentsAutophagyCholesterolHumansLysosomesMacrophagesMycobacterium tuberculosisPhosphorylationSignal TransductionSimvastatinMiceBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsAMP-Activated Protein Kinases

Keywords

TFEBAutophagySimvastatinmTORC1AMPKChemistryCholesterolCell biologyPharmacologyPI3K/AKT/mTOR pathwayMedicineBiochemistryBiologySignal transductionKinaseProtein kinase AMycobacterium tuberculosisLipidsimmunologystatinsMacrophages/monocytesAdenosine 5′-Monophosphate-activated Protein Kinase-mechanistic Target Of Rapamycin Complex 1-Transcription Factor Eb AxisMechanistic Target Of Rapamycin Complex 1 Regulation

Sustainable Development Goals

SDG 0: Good health and well-being

The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis

FAIR Checklist

Authors (7)

Funding (8 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)