γ-Tubulin participates in the formation of the midbody during cytokinesis in mammalian cells is a research paper published in Journal of Cell Science (1993). On theSindex it has a DataRank of 8.5. It has been cited 154 times, with 145 citing works in its 1-hop citation network.
ABSTRACT Animal cells undergoing cytokinesis form an inter-cel-lular bridge containing two bundles of microtubules interdigitated at their plus ends, which constitute the midbody. Polyclonal antibodies raised against three specific amino acid sequences of γ-tubulin (EEFATEGGDRKDV, NIIQGEADPTDVHKSL and EYHAATRPDYISWGTQEQ) specifically stained the centrosome in interphase, the spindle poles in all stages of mitosis, and the extremities of the midbody in mam-malian cells (Potorous, human, Chinese hamster, mouse). This staining was prevented by the corre-sponding peptides, by Xenopus γ-tubulin, but was not modified by purified αγ-tubulin heterodimer. An iden-tical staining was obtained with affinity-purified anti-bodies against the carboxyl-terminal amino acid sequence of human γ-tubulin. No γ-tubulin could be detected in the interzone during anaphase and early telophase. Material containing γ-tubulin first appeared in the two daughter cells on each side of the division plane in late telophase, and accumulated transiently at the minus ends of the two microtubule bundles consti-tuting the midbody for one hour after metaphase. Micro-injection of γ-tubulin antibodies into anaphase cells prevented the subsequent formation of the micro-tubule bundles between the two daughter cells. In con-trast with previous views, these observations suggest that the microtubules constituting the midbody may be nucleated on special microtubule organizing centres, active during late telophase only, and assembled on each side of the dividing plane between the daughter cells.
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Base Score Contribution
0.757
From this paper's citation signal
Citation Network Contribution
7.8
From 138 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 9% comes from its base citations and 91% from the citation network (138 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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