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Inhibition of Hedgehog signaling does not mitigate polycystic kidney disease severity in a Pkd1 mutant mouse model

Journal of Cell Science(2025)10.1242/jcs.264133Source: DataRank Database

Inhibition of Hedgehog signaling does not mitigate polycystic kidney disease severity in a Pkd1 mutant mouse model is a research paper published in Journal of Cell Science (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 2.89)OA: greenTopics (56)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Scott Houghtaling ORCID,Tzu-Hua Ho ORCID,David R. Beier ORCID,Sean Gombart

Live enrichment

PubMed:40554762 PMC:PMC12377710 OpenAlex:https://openalex.org/W4411587144

National Institutes of Health

Grant: R01DK111682

NIDDK NIH HHS

Grant: R01 DK066370

NIH HHS

Grant: S10 OD032302

FWCI

2.89

Citation Percentile

0.9%

Citation Trend

2025

greenLicense: http://www.biologists.com/user-licence-1-2/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12377710/

publisherhttps://journals.biologists.com/jcs/article-pdf/doi/10.1242/jcs.264133/3653572/jcs264133.pdf

publisherhttps://journals.biologists.com/jcs/article-pdf/doi/10.1242/jcs.264133/3659149/jcs264133.pdf

journalhttps://doi.org/10.1242/jcs.264133

Fields of Study

Genetic and Kidney Cyst DiseasesHedgehog Signaling Pathway StudiesEpigenetics and DNA MethylationAnimalsHedgehog ProteinsSignal TransductionTRPP Cation ChannelsMiceDisease Models, AnimalZinc Finger Protein GLI1CiliaPolycystic Kidney, Autosomal DominantPolycystic Kidney DiseasesSmoothened ReceptorMutationZinc Finger Protein Gli2Zinc Finger Protein Gli3X-Ray MicrotomographyKruppel-Like Transcription FactorsKidneyNerve Tissue Proteins

MeSH Terms

Zinc Finger Protein GLI1Smoothened ReceptorZinc Finger Protein Gli3Zinc Finger Protein Gli2AnimalsCiliaDisease Models, AnimalKidneyPolycystic Kidney DiseasesMutationNerve Tissue ProteinsSignal TransductionPolycystic Kidney, Autosomal DominantTRPP Cation ChannelsMiceKruppel-Like Transcription FactorsHedgehog ProteinsX-Ray Microtomography

Keywords

BiologyPKD1Polycystic kidney diseaseMutantPolycystic kidneyHedgehogHedgehog signaling pathwayDiseaseCell biologyKidneySignal transductionGeneticsInternal medicineEndocrinologyGeneHedgehog SignalingMouse Disease Models

Sustainable Development Goals

SDG 0: Good health and well-being