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Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM]

Wellcome Open Research(2021)10.12688/wellcomeopenres.16783.1Source: DataRank Database

Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM] is a research paper published in Wellcome Open Research (2021). On theSindex it has a DataRank of 0.554. It has been cited 13 times, with 7 citing works in its 1-hop citation network.

N/A

0.554DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access13 citations · 7 citing works in its network

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Linked data & code

nct doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

figshare10.6084/m9.figshare.14508561
ClinicalTrials.govNCT03927313

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 2.23)OA: goldTopics (26)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 72%Citation Network 28%

Base Score Contribution

0.396

From this paper's citation signal

Citation Network Contribution

0.158

From 5 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 7 citers.

Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs
Nature Communications202417 citations60 referencesContributes 0.048
Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis
International Journal of Antimicrobial Agents20239 citations51 referencesContributes 0.045
Treatment and Toxicity Considerations in Tuberculosis: A Narrative Review
Cureus20246 citations45 referencesContributes 0.043
Advances in the Treatment and Clinical Management Strategies of Tuberculous Meningitis
International Journal of General Medicine20253 citations45 referencesContributes 0.031
Bacterial meningitis in Africa
Frontiers in Neurology202353 citations219 referencesContributes 0.018

Authors (38)

Sean Wasserman ORCID,Mpumi Maxebengula,Cari Stek ORCID,Marise Bremer,Remy Daroowala

Live enrichment

PubMed:34286103 PMC:PMC8283551 OpenAlex:https://openalex.org/W3171520007

National Research Foundation

Grant: 64787

Medical Research Council

Grant: MRC/R008922/1

Wellcome Trust

Grant: 104803

Host directed therapies against tuberculosis.

Wellcome Trust

Grant: 203135

Centre for Infectious Diseases Research in Africa (CIDRI-Africa)

Wellcome Trust

Grant: 175479

Wellcome Trust

Grant: FC0010218

Wellcome Trust

Grant: 214321

Evaluation of novel therapeutic strategies to accelerate bacterial clearance and host recovery in disseminated HIV-associated tuberculosis

European and Developing Countries Clinical Trials Partnership

Grant: CDF1018

National Institutes of Health

Grant: K43TW011421

National Institutes of Health

Grant: R01AI45436

Medical Research Council

Grant: MR/R008922/1

NIAID NIH HHS

Grant: R01 AI145436

The Francis Crick Institute

Grant: 10218

National Institutes of Health

Grant: 1K43TW011421-01

Characterizing the pharmacokinetics of high dose rifampicin and linezolid in a randomized controlled trial for HIV-associated tuberculous meningitis

Wellcome Trust

Meningitis Now

FWCI

2.23

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://wellcomeopenresearch.org/articles/6-136/v1/pdf

publisherhttps://wellcomeopenresearch.org/articles/6-136/v1/pdf

publisherhttps://wellcomeopenresearch.org/articles/6-136/v1/xml

publisherhttps://wellcomeopenresearch.org/articles/6-136/v1/iparadigms

journalhttps://doi.org/10.12688/wellcomeopenres.16783.1

Fields of Study

Infectious Diseases and TuberculosisTuberculosis Research and EpidemiologyPneumocystis jirovecii pneumonia detection and treatment03 medical and health sciences0302 clinical medicine

Keywords

MedicineTolerabilityContext (archaeology)LinezolidRifampicinAdverse effectTuberculosisClinical endpointTuberculous meningitisRegimenInternal medicineSurgeryRandomized controlled trialMeningitisPathologyVancomycinHIVaspirinStudy Protocol610600

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Related Papers (2)

Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

N/A

1.3DataRank · unranked

Trials(2022)

co-cited

10.1186/s13063-022-06772-1

Comparative Pharmacokinetic Study for Linezolid and Two Novel Antibacterial Oxazolidinone Derivatives in Rabbits: Can Differences in the Pharmacokinetic Properties Explain the Discrepancies between Their In Vivo and In Vitro Antibacterial Activities?

N/A

0.736DataRank · unranked

Pharmaceutics(2017)

co-cited

10.3390/pharmaceutics9030034

Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM]

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (38)

Funding (16 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)

Related Papers (2)